{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:10:44Z","timestamp":1791252644173,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Oral mucosal melanoma (OMM) is a rare subtype of melanoma but exhibits highly invasive biological behavior. Programmed cell death protein 1 (PD\u20101) monotherapy showed lower response in OMM than other subtypes of melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the efficacy and safety of pembrolizumab with anlotinib in patients with advanced OMM between August 2018 and September 2024. The primary endpoint was objective response rate (ORR); the secondary endpoints included disease control rate (DCR), duration of response (DOR), progression\u2010free survival (PFS), overall survival (OS), and treatment\u2010related adverse events (TRAEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010one patients were enrolled in our study. Seventeen patients (41.4%) achieved an objective response. The median PFS was 6.4\u2009months (95% confidence interval [CI], 4.5\u20138.3\u2009months), and the median OS was 10.0\u2009months (95% CI, 8.3\u201311.7\u2009months). Thirty\u2010three patients (80.5%) experienced at least one TRAE. The most common TRAEs were hypertension (29.3%), hand\u2010foot syndrome (19.5%), and anemia (19.5%). Grade 3 or higher TRAEs occurred in two patients (4.8%), and no grade 5 TRAEs were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggested that pembrolizumab with anlotinib in patients with advanced OMM showed potential efficacy and manageable adverse effects. Further studies are needed to confirm the efficacy of this combination strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70206","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:53:51Z","timestamp":1770695631000},"page":"1308-1314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pembrolizumab With Anlotinib in Advanced Oral Mucosal Melanoma: A Retrospective Trial"],"prefix":"10.1111","volume":"32","author":[{"given":"Yun","family":"Bi","sequence":"first","affiliation":[{"name":"School of Stomatology Shandong Second Medical University  Weifang China"},{"name":"Department of Oral Maxillofacial\u2010Head and Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Clinical Research Center of Stomatology  Shanghai 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