{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:51:01Z","timestamp":1790787061777,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mucosal\u2010dominant pemphigus vulgaris (MD\u2010PV) and low\u2010risk mucous membrane pemphigoid (LR\u2010MMP) are autoimmune bullous diseases primarily affecting the oral mucosa, yet their oral microbiome profiles remain inadequately characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using 16S rRNA sequencing of saliva from 21 MD\u2010PV patients, 26 LR\u2010MMP patients, and 14 healthy controls (HC), we analyzed microbial diversity, differential taxa (LEfSe), and functional potential (PICRUSt2\/BugBase).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both patient groups showed significant microbial restructuring without major richness changes, featuring increased Firmicutes and decreased Proteobacteria. Disease\u2010specific signatures included Flavobacteriia enrichment in MD\u2010PV and Coriobacteriia\/Actinobacteria in LR\u2010MMP. Shared metabolic alterations involved \u201cBiosynthesis of amino acids,\u201d \u201cPhosphotransferase system,\u201d and \u201cRibosome\u201d pathways, while distinct activations included \u201call\u2010trans\u2010farnesol biosynthesis\u201d in MD\u2010PV and \u201cpeptidoglycan biosynthesis\u201d in LR\u2010MMP. Phenotype prediction revealed increased Gram\u2010positive bacteria and reduced pathogenic and stress\u2010tolerant taxa. Microbial dysbiosis scores positively correlated with clinical disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study identifies distinct oral microbial dysbiosis patterns in MD\u2010PV and LR\u2010MMP, with conserved functional shifts and disease\u2010specific metabolic adaptations. The microbiota\u2010severity correlation highlights its potential role in disease mechanisms, offering new insights for therapeutic exploration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry (ChiCTR): ChiCTR2500105460<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70207","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T04:21:47Z","timestamp":1768796507000},"page":"1347-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral Microbial Dysbiosis and Pathogenic Functional Shifts in Mucosa\u2010Dominant Pemphigus Vulgaris and Low\u2010Risk Mucous Membrane Pemphigoid"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-3016","authenticated-orcid":false,"given":"Lin","family":"Ye","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Ruan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; 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National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-3366","authenticated-orcid":false,"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Research Unit of Oral Carcinogenesis and Management &amp; Chinese Academy of Medical Sciences West China Hospital of Stomatology, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0242-6628","authenticated-orcid":false,"given":"Tiannan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; 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