{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:05:58Z","timestamp":1781010358110,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100025324","name":"\u0130zmir K\u00e2tip \u00c7elebi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare salivary levels of galectin\u20108, galectin\u20109, and RANKL in individuals with gingivitis, periodontitis, and healthy periodontium, and to evaluate their diagnostic potential in periodontal diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 60 systemically healthy, non\u2010smoking individuals were included in this cross\u2010sectional study. Participants were divided into three groups based on periodontal examination: healthy (Group H,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), gingivitis (Group G,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), and periodontitis (Group P,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920). Clinical periodontal parameters were recorded. Salivary biomarker levels were analyzed using ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All biomarkers were significantly elevated in groups G and P compared to group H (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and higher in group P than group G (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). ROC analysis revealed that galectin\u20109 (AUC\u2009=\u20090.946) was significantly better at distinguishing periodontal disease than galectin\u20108 (AUC\u2009=\u20090.832) and RANKL (AUC\u2009=\u20090.780) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No significant difference was observed between galectin\u20108 and RANKL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Salivary galectin\u20108, galectin\u20109, and RANKL levels are elevated in periodontal disease and may serve as diagnostic biomarkers. Among them, galectin\u20109 demonstrated superior discriminative power for identifying periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT06404476<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70213","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:40:56Z","timestamp":1768891256000},"page":"1119-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Salivary Galectin\u20108, Galectin\u20109, and\n                    <scp>RANKL<\/scp>\n                    Levels in Periodontal Health and Disease"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0266-0720","authenticated-orcid":false,"given":"K\u00fcbra Ayd\u0131n","family":"Er","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-5561","authenticated-orcid":false,"given":"Huriye Erbak","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine Izmir Katip Celebi University  Izmir Turkey"},{"name":"Izmir Biomedicine Genome Center Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2643-9575","authenticated-orcid":false,"given":"Figen","family":"Narin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine Izmir Katip Celebi University  Izmir 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