{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:06:21Z","timestamp":1781010381856,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This trial aimed to assess the adjunctive therapeutic effect of low\u2010intensity pulsed ultrasound (LIPUS) in promoting bone regeneration following jaw cyst enucleation with curettage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This triple\u2010blinded, randomized trial enrolled 29 patients (33 jaw cysts) undergoing enucleation. 17 patients (18 cysts) received daily LIPUS therapy for 10 days (Ultrasound group), while 12 patients (15 cysts) received sham LIPUS therapy (control group). Volumetric changes of the cystic cavities and bone density (relative Hounsfield units) were assessed at baseline, at 3, and 6\u2009months following LIPUS therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the 3rd month, a significant reduction in cyst volume was observed in the Ultrasound group, which showed a 63% reduction, compared to a 35% reduction in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). By the 6th month, the Ultrasound group demonstrated a further decrease in volume compared to the control group (82% vs. 61%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). Moreover, LIPUS therapy consistently resulted in significantly greater bone density than the control group at both 3 and 6\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjunctive LIPUS therapy following jaw cyst enucleation improves bone regeneration postoperatively without adverse effects. LIPUS is a promising non\u2010invasive method for promoting bone healing post\u2010enucleation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Thailand Clinical Trials Registry on June 16, 2025 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.thaiclinicaltrials.org\/show\/TCTR20250616017\">https:\/\/www.thaiclinicaltrials.org\/show\/TCTR20250616017<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70224","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:44:20Z","timestamp":1769748260000},"page":"1093-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive Low\u2010Intensity Pulsed Ultrasound Therapy for Bone Regeneration Following Jaw Cyst Enucleation With Curettage"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-8279","authenticated-orcid":false,"given":"Sadam Ahmed","family":"Elayah","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Centre for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Oral &amp; Maxillofacial Surgery, College of Dentistry University of Ibn Al\u2010Nafis for Medical Sciences  Sana'a Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Centre for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Centre for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhe","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Centre for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Centre for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-4408","authenticated-orcid":false,"given":"Jie","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Centre for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-024-00441-1"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.04.009"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13355"},{"issue":"1","key":"e_1_2_14_5_1","first-page":"131","article-title":"What Surgical Treatment Has the Lowest Recurrence Rate Following the Management of Keratocystic Odontogenic Tumor?: A Large Systematic Review and Meta\u2010Analysis","volume":"45","author":"Al\u2010Moraissi E. 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