{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:52:08Z","timestamp":1790272328637,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) requires reliable prognostic markers for treatment planning. Intratumoral budding (ITB) is a histopathological parameter shown to have prognostic relevance in several malignancies. This study evaluated the prognostic utility of ITB in pre\u2010operative OSCC biopsies compared with World Health Organization (WHO) histological grading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An ambispective cohort of 42 pre\u2010operative OSCC cases (well and moderately differentiated squamous cell carcinoma) with corresponding resection reports (January 2022\u2013April 2025) was analyzed. ITB was assessed on hematoxylin and eosin\u2013stained sections using International Tumor Budding Consensus Conference criteria, including TB0. Clinicopathological parameters and survival outcomes\u2014disease\u2010free survival (DFS) and overall survival (OS)\u2014were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ITB positivity correlated significantly with higher nodal stage, tumor\u2013node\u2013metastasis stage, depth of invasion, perineural invasion, and extracapsular spread (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). ITB\u2010positive cases showed reduced DFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) and OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), with worsening DFS across increasing ITB grades (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). Cox regression demonstrated higher hazard ratios for ITB positivity (DFS: HR 47.93, 95% CI 0.12\u201318,571.86; OS: HR 49.80, 95% CI 0.14\u201318,238.87), though not statistically significant. WHO grading showed no significant survival associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single\u2010center, small cohort, ITB demonstrated stronger associations with adverse features and survival than WHO grading, warranting validation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70233","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T04:21:59Z","timestamp":1771820519000},"page":"1848-1853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intratumoral Budding in Preoperative Biopsies of Oral Squamous Cell Carcinoma: Prognostic Value in Comparison With WHO Grading"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-176X","authenticated-orcid":false,"given":"R.","family":"Keerthika","sequence":"first","affiliation":[{"name":"Faculty of Dental Sciences, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-6930","authenticated-orcid":false,"given":"Akhilesh","family":"Chandra","sequence":"additional","affiliation":[{"name":"Faculty of Dental Sciences, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-5328","authenticated-orcid":false,"given":"Rahul","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Faculty of Dental Sciences, Institute of Medical Sciences Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-025-00796-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23380"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.425"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13104"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205454"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13173"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.07.009"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16397"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.18295\/2075-0528.1008"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.03.019"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14070"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001241"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.56"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_331_19"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-025-05690-3"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.46"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2057178X17738912"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/jiaomr.jiaomr_261_23"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2023.8650"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010134"},{"issue":"1","key":"e_1_2_12_23_1","article-title":"Comparison Between Peritumoral and Intratumoral Budding in Colorectal Cancer","volume":"12","author":"Pyo J. 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