{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:01:26Z","timestamp":1789966886412,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study evaluated the CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell role in mediating post\u2010Rituximab Pemphigus vulgaris (PV) relapse, comparing CD4\n                      <jats:sup>+<\/jats:sup>\n                      count and CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD20\n                      <jats:sup>+<\/jats:sup>\n                      ratio between patients who achieved remission and those who relapsed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The clinical course of 27 PV patients treated with Rituximab was evaluated after a 32\u2010month median follow\u2010up. CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD20\n                      <jats:sup>+<\/jats:sup>\n                      counts and CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD20\n                      <jats:sup>+<\/jats:sup>\n                      ratio were longitudinally collected at treatment start date (T0), at 2\u2010month intervals after Rituximab, until B\u2010cell repopulation, at B\u2010cell repopulation, at 6\u2010, 12\u2010, and 24\u2010month intervals after repopulation, and at the end of follow\u2010up or at relapse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were administered Rituximab as adjuvant therapy: 16 (59%) relapsed while 11 (41%) achieved clinical remission. Higher CD4\n                      <jats:sup>+<\/jats:sup>\n                      count (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02*) and CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD20\n                      <jats:sup>+<\/jats:sup>\n                      ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004**) were found at B\u2010cell repopulation in patients experiencing remission. Moreover, a significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002**) in post\u2010repopulation CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell course was found between groups, with patients in clinical remission reporting a mean decrease of 233.5\u2009cells\/\u03bcL during follow\u2010up and relapsing patients experiencing a mean increase of 539.4\u2009cells\/\u03bcL and reaching the maximum CD4\n                      <jats:sup>+<\/jats:sup>\n                      value at relapse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Lower CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell value at repopulation and increasing post\u2010repopulation CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell count were predictive of disease relapse suggesting a time\u2010dependent role of CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells in post\u2010Rituximab PV reactivation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70234","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:29:25Z","timestamp":1775705365000},"page":"1959-1967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CD4+ T Cells Predict Relapse in Pemphigus Vulgaris Treated With Rituximab: A Retrospective Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5303-0855","authenticated-orcid":false,"given":"Simone","family":"Liguori","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Reproductive and Odontostomatological Sciences 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