{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:03:42Z","timestamp":1789967022606,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2402900"],"award-info":[{"award-number":["2022YFC2402900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a chronic immune\u2010mediated inflammatory disease with malignant potential, and its local inflammatory microenvironment is closely related to mucosal\u2010associated invariant T cells (MAIT). Our prior work established OLP\u2010associated fibroblasts (OLP\/AFs) in creating the inflammatory milieu, but their interaction with MAIT cells remains unexplored. This study aims to investigate how OLP\/AFs interact with MAIT cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Oral mucosal samples from OLP patients and healthy controls were selected for flow cytometry to detect MAIT cells. MR1 expression on fibroblasts was quantified via RT\u2010qPCR, Western blot, immunohistochemistry, and immunofluorescence. For functional assays, OLP\/AFs were stimulated with formaldehyde\u2010fixed\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Escherichia coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E. coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) to induce MR1 surface expression, then co\u2010cultured with PBMCs\u00b1anti\u2010MR1 blocking antibody and evaluated the activation status of MAIT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MR1 expression and MR1\n                      <jats:sup>+<\/jats:sup>\n                      fibroblast density were significantly elevated in OLP lesions compared to healthy controls. OLP\/AFs demonstrated higher baseline MR1 expression than normal fibroblasts, which was further enhanced following\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E.\u2009coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      stimulation. Co\u2010culture of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E.\u2009coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010stimulated OLP\/AFs with peripheral blood mononuclear cells induced marked activation of MAIT cells. This was evidenced by significantly increased frequencies of CD69\n                      <jats:sup>+<\/jats:sup>\n                      MAIT cells and elevated secretion of pro\u2010inflammatory cytokines and cytotoxic molecules.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OLP\/AFs activate MAIT cells via an MR1\u2010dependent mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70238","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:20:28Z","timestamp":1770960028000},"page":"1968-1979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>MR1<\/scp>\n                    \u2010Mediated Activation of Mucosal\u2010Associated Invariant T Cells by Oral Lichen Planus\u2010Associated Fibroblasts"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-9835","authenticated-orcid":false,"given":"Xiaoli","family":"Wu","sequence":"first","affiliation":[{"name":"Stomatological Hospital, School of Stomatology Southern Medical University  Guangzhou P.R. China"},{"name":"Liwan District Stomatological Hospital  Guangzhou Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Mi","sequence":"additional","affiliation":[{"name":"Stomatological Hospital, School of Stomatology Southern Medical University  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Stomatological Hospital, School of Stomatology Southern Medical University  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Stomatological Hospital, School of Stomatology Southern Medical University  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Stomatological Hospital, School of Stomatology Southern Medical University  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2471-633X","authenticated-orcid":false,"given":"Wenxia","family":"Meng","sequence":"additional","affiliation":[{"name":"Stomatological Hospital, School of Stomatology Southern Medical University  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201060449\u2010w"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004621\u2010y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.578548"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302701"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021490"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1023213"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758\u20105090\/ac925a"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4TA0815\u2010391RR"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201008\u2010303339"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.048"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000407"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100908"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.03.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600602"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20108935\u20105_26"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010022\u201001600\u20103"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15057"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010018\u20101799\u20101"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1890"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.09.009"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1585020"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3416"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12022"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u20100345\u2010y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010080719\u2010015428"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.2010.00946.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5383099"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007207\u20109"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11653"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201005\u2010353789"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaw0402"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110175"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010018\u20100656\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004959\u20103"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9722"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13250"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14613"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0904\u20102512.2001.10063.x"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:13:18Z","timestamp":1789963998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/odi.70238"],"URL":"https:\/\/doi.org\/10.1111\/odi.70238","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.70238\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70238\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70238\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70238\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70238\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70238\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"2025-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}