{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:01:12Z","timestamp":1789966872856,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To ascertain the causal relationship between non\u2010surgical periodontal therapy (NSPT) and incident hypertension and to investigate the mediating role of systemic inflammation in this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of patients diagnosed with periodontitis between 2015 and 2021 at our institution. Participants were stratified into two groups: those who received NSPT (treatment group) and those who did not (control group). Elevated systemic inflammation was assessed using composite inflammatory markers measured from initial treatment through 1\u2009year after diagnosis. The primary outcome was the development of hypertension during follow\u2010up. Causal mediation analysis evaluated the mediating role of inflammation in the NSPT\u2010hypertension association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 228 included patients (43% male, median age: 50.5\u2009years), 47 (20.6%) developed hypertension during a median follow\u2010up of 4.34\u2009years (IQR 3.41\u20135.60). The average direct effect of NSPT on hypertension risk was consistent (control: \u22120.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012; treatment: \u22120.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), indicating a stable protective effect. However, the mediation effect of elevated systemic inflammation was nonsignificant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05), with a negligible proportion of the total effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NSPT was causally linked to reduced risk of incident hypertension, but not via systemic inflammatory pathways. Alternative mechanisms warrant investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70239","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:30:51Z","timestamp":1772998251000},"page":"2039-2048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediating Effects of Systemic Inflammation in the Association Between Non\u2010Surgical Periodontal Therapy (\n                    <scp>NSPT<\/scp>\n                    ) and Hypertension: Testing a Hypothesis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4445-4456","authenticated-orcid":false,"given":"Wei","family":"He","sequence":"first","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Department of Stomatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-4654","authenticated-orcid":false,"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Yidu Cloud Technology Inc.  Beijing China"},{"name":"Nanjing YiGenCloud Institute  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Department of Stomatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiehan","family":"Cui","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Department of Stomatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiming","family":"Xu","sequence":"additional","affiliation":[{"name":"Yidu Cloud Technology Inc.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangling","family":"Dai","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Department of Stomatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Information Department, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-8906","authenticated-orcid":false,"given":"Linfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Yidu Cloud Technology Inc.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liao","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Department of Stomatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi 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