{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:02:38Z","timestamp":1789966958021,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study evaluated the efficacy and safety of hypericin\u2010mediated photodynamic therapy (PDT) for oral\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Candida albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) infections and explores how\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      reduction mediates clinical improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 107 patients (March 2023\u2013March 2025) were assigned to a control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951, conventional antifungal therapy) or a study group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200957, hypericin + PDT). Post\u2010treatment assessments included oral microbiota structure, \u03b1\u2010diversity (Chao1, Shannon, Simpson), community differences (via PCoA and hierarchical clustering), and a mediation model to test\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">C. albicans<\/jats:styled-content>\n                        '\n                      <\/jats:italic>\n                      role in lesion improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chao1 (species richness) showed no significant difference, but the study group had lower Shannon\/Simpson (microbial diversity). Opportunistic pathogens (e.g.,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      , Fusobacterium) decreased, while beneficial bacteria (e.g., Lactobacillus) increased. PCoA\/clustering confirmed distinct community structures.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      reduction mediated 53.1% of lesion size reduction (indirect effect\u2009=\u2009\u22122.656; 95% CI: 0.178\u20135.755).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Hypericin + PDT effectively treats oral\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      infections safely.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      is the core mediator for lesion area reduction, providing a basis for targeted clinical therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70240","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:50:51Z","timestamp":1771210251000},"page":"1980-1989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Efficacy and Safety of Hypericin\u2010Mediated Photodynamic Therapy for Oral\n                    <i>Candida albicans<\/i>\n                    Infections"],"prefix":"10.1111","volume":"32","author":[{"given":"Xuan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Stomatology Changsha Medical University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of 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