{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:01:12Z","timestamp":1789966872684,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluated the efficacy of photobiomodulation (PBM) at acupuncture points for managing xerostomia in patients with Sj\u00f6gren's Disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized, double\u2010blind clinical trial, 50 patients were assigned to PBM group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) or sham\u2010PBM group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928). The primary outcome was xerostomia symptoms assessed using a visual analogue scale (VAS). Secondary outcomes included Xerostomia Inventory, resting salivary flow rate (RSFR), and EULAR Sj\u00f6gren's Syndrome Patient Reported Index score. Participants received weekly PBM sessions for four consecutive weeks, and evaluations were conducted at baseline, week 8 and 12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PBM showed a marginal tendency toward improvement on VAS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0974) (OR\u2009=\u20091.929 95% CI 0.8939\u20134.525) and in the RSFR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09996) (OR\u2009=\u2009+infinity 95% CI 0.9363\u2010infinity) at week 8 compared with sham\u2010PBM. However, no statistically significant differences were observed between groups at week 12 for any of the assessed outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PBM at acupuncture points demonstrated a slight short\u2010term benefit at week 8 in improving xerostomia symptoms and RSFR, although these effects did not persist at 12\u2009weeks. These preliminary results suggest a potential role for PBM at acupuncture points as a safe, noninvasive adjunctive therapy for xerostomia in patients with SjD, warranting further validation in larger, long\u2010term trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study was registered in The Brazilian Registry of Clinical Trials (U1111\u20101298\u20109891)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70241","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:35:19Z","timestamp":1776749719000},"page":"1912-1922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laser Acupuncture on the Management of Xerostomia in Sj\u00f6gren's Disease: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-1294","authenticated-orcid":false,"given":"Matheus Ferreira","family":"Linares","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, Semiology and Pathology Areas, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tain\u00e1 Duarte","family":"dos Santos Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Private Office  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara Barros Madureira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Private Office  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Gomes","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of Pernambuco  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Luzia Branco Pinto","family":"Duarte","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Hospital das Cl\u00ednicas Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-4318","authenticated-orcid":false,"given":"Luiz Alcino","family":"Gueiros","sequence":"additional","affiliation":[{"name":"Department of Clinic and Preventive Dentistry, Oral Medicine Unit Federal University of Pernambuco (UFPE), School of Dentistry  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12313"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010018\u20102124\u2010x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2018.03.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010024\u201001135\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.05.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)02251\u20100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.47"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010014\u20101590\u20108"},{"issue":"6","key":"e_1_2_11_10_1","first-page":"365","article-title":"SJ \u2010 cartee","volume":"89","author":"Cartee D. 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