{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:01:12Z","timestamp":1789966872743,"version":"4.0.1"},"reference-count":80,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570995"],"award-info":[{"award-number":["81570995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To summarize current understanding of the roles of AMP\u2010activated protein kinase (AMPK) in maintaining salivary gland (SG) homeostasis and its therapeutic potential in SG disorders characterized by acinar atrophy and fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Recent studies and reviews on AMPK signaling, salivary gland pathology, and tissue regeneration were collected from PubMed, Medline, and Scopus databases. The evidence was synthesized to elucidate the regulatory functions of AMPK in SG injury and recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SG homeostasis relies on a balance between cell death and renewal, which is disrupted by severe damage. AMPK functions as a pivotal regulator in this process, promoting acinar cell survival, activating resident stem cells, inhibiting fibrosis, and modulating immune responses. AMPK activation attenuates inflammation and fibrogenesis, enhances tissue regeneration, and fosters a reparative immune microenvironment conducive to glandular recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AMPK serves as a central hub linking metabolic regulation, immune modulation, and tissue repair in SG disorders. Understanding its molecular mechanisms and optimizing AMPK activation strategies may provide novel therapeutic approaches to restore both function and structure in damaged salivary glands.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70242","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:46:57Z","timestamp":1770958017000},"page":"1756-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Emerging Role of\n                    <scp>AMPK<\/scp>\n                    in Salivary Gland: From Disorder to Recovery"],"prefix":"10.1111","volume":"32","author":[{"given":"Xufei","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology, Department of Oral and Cranio\u2010Maxillofacial Science, Center of Craniofacial Orthodontics, National Clinical Research Center of Stomatology Shanghai Research Institute of Stomatology, Shanghai Jiaotong University School of Medicine, Ninth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"},{"name":"Department of Oral Radiology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-8761","authenticated-orcid":false,"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"issue":"10","key":"e_1_2_13_2_1","first-page":"12509","article-title":"Berberine Regulates Proliferation, Collagen Synthesis and Cytokine Secretion of Cardiac Fibroblasts via AMPK\u2010mTOR\u2010p70S6K Signaling Pathway","volume":"8","author":"Ai F.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1190386"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231222871"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010024\u201001135\u20103"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201019095\u2010z"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294355"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201050877\u20109"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2021.2011310"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153232"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3460659"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2021"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.4172\/2165\u20107386.1000180"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004772\u20106"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2022.105479"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063878"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7928"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.08.020"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00414"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010017\u20100054\u2010z"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201010\u2010417"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105844"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.102346"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511405330"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110063"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024619\u20102"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.04.19.537577"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010019\u20100324\u20105"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201002011\u2010y"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010024\u201001246\u20103"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.16\u201031"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.12.028"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102335"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.03.055"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010019\u20101904\u20100"},{"issue":"6","key":"e_1_2_13_37_1","first-page":"550","article-title":"Salivary Gland Disorders: Rapid Evidence Review","volume":"109","author":"Kim M. 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