{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:02:23Z","timestamp":1789966943329,"version":"4.0.1"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007683","name":"Nihon University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>To evaluate naturally occurring cellular senescence in human gingival and periodontal ligament (PDL) tissues by addressing two questions: (1) whether susceptibility to cellular senescence increases with chronological aging, and (2) whether periodontitis lesions exhibit senescence\u2010associated features indicative of inflammation\u2010accelerated senescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A structured search of PubMed and bioRxiv databases identified 186 articles. After applying the inclusion criteria, 13 studies that investigated senescence markers in gingival and PDL tissues in the context of aging or periodontitis were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed tissue\u2010specific senescence. Gingival fibroblasts exhibited progressive age\u2010related senescence. In contrast, PDL fibroblasts showed consistently high baseline senescence regardless of age, whereas PDL stem cells exhibited age\u2010related decline in regenerative potential. In periodontitis\u2010affected tissues, senescence markers\u2014such as p16, SA\u2010\u03b2\u2010gal, and SASP\u2010related factors\u2014were elevated compared to healthy tissues, even among younger individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion(s)<\/jats:title>\n                    <jats:p>Senescence is a key biological feature of periodontal tissues with distinct cell\u2010type\u2013specific dynamics. These findings suggest that aging and inflammation contribute to the accumulation of senescent cells, which may influence periodontal health and disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70258","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T04:25:31Z","timestamp":1771820731000},"page":"1780-1792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cellular Senescence in Human Periodontal Tissue: A Narrative Review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-2076","authenticated-orcid":false,"given":"Akira","family":"Hasuike","sequence":"first","affiliation":[{"name":"Department of Periodontology Nihon University School of Dentistry  Chiyoda\u2010ku Tokyo Japan"},{"name":"Dental Research Center Nihon University School of Dentistry  Chiyoda\u2010ku Tokyo 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