{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:01:12Z","timestamp":1789966872770,"version":"4.0.1"},"reference-count":70,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To expand the clinicopathological, immunohistochemical, and molecular spectrums of head and neck NUT carcinoma (HN\u2010NC) of rare sites and explore potential prognostic factors and treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>HN\u2010NCs were confirmed by NUT immunostaining, fluorescence in\u00a0situ hybridization and\/or next generation sequencing. Immunohistochemistry for therapeutic markers and follow\u2010up were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen HN\u2010NCs were collected. Most involved major salivary gland (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) and oral mucosa (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). Other sites included mandible (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), and maxilla (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092). Nine out of 13 harbored\n                      <jats:italic>BRD4::NUTM1<\/jats:italic>\n                      fusion while the others carrying rare\n                      <jats:italic>ZNF532::NUTM1<\/jats:italic>\n                      , novel\n                      <jats:italic>CCNT2::NUTM1<\/jats:italic>\n                      and\n                      <jats:italic>WHSC1L1::NUTM1<\/jats:italic>\n                      fusion respectively. Microscopically, three unusual morphologies were observed, resembling differentiated papillary squamous cell carcinoma, myoepithelial carcinoma and small round cell malignancy, respectively. SOX2, PRAME, c\u2010MYC, EGFR showed positive staining in around half cases. During the average follow\u2010up time of 12.8\u2009months, 3\/13 patients suffered recurrence, 5 had distant metastasis and 5 died of disease. Integrating with published reports, Kaplan\u2013Meier method revealed that tumor site was associated with overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039), and fusion gene type was associated with disease\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HN\u2010NCs had dismal prognosis, especially those originating from oral mucosa. HN\u2010NC should be included in the differential diagnosis when encountering poorly differentiated\/undifferentiated malignancies or carcinomas with squamous differentiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70269","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:16:18Z","timestamp":1772979378000},"page":"1873-1888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expanding the Morphological, Immunohistochemical, and Molecular Spectrums of NUT Carcinoma at Rare Sites of Head and Neck Region"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-8258","authenticated-orcid":false,"given":"Jingjing","family":"Sun","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, National Center for Stomatology, 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