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This study describes salivary proteome patterns observed in a small female JS cohort to characterize the oral molecular environment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Unstimulated saliva was collected from three related female JS patients carrying\n                      <jats:italic>CNNM4<\/jats:italic>\n                      c.1475G&gt;A (p.Gly492Asp) and six age\u2010matched female unaffected controls. Tandem mass tag (TMT)\u2013based quantitative proteomics was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010seven uniquely quantified salivary proteins were identified. Thirty\u2010three proteins showed higher abundance in JS saliva (log2FC &gt;\u20090.6; adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), including neutrophil\/innate immune proteins (MPO, CTSG, SERPINB1) and carbohydrate\u2010metabolism enzymes (ENO1\/ENO2, GAPDH, TKT, TALDO1). LDHA showed a group\u2010specific detection pattern, being detected in all JS samples but not detected in controls under the current workflow. Functional annotation and interaction analyses highlighted themes related to innate immunity and carbohydrate metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this small female\u2010only cohort, the salivary proteome profile observed in JS was characterized by increased abundance of proteins annotated to innate immune defense and carbohydrate\u2010associated metabolic processes. These findings are descriptive and should be interpreted in the context of oral clinical status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70273","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:21:08Z","timestamp":1774412468000},"page":"1938-1947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Saliva Proteomics Shows Immune Activation and Metabolic Shifts in Female Jalili Syndrome Patients"],"prefix":"10.1111","volume":"32","author":[{"given":"Khanti","family":"Rattanapornsompong","sequence":"first","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-1983","authenticated-orcid":false,"given":"Kanokwan","family":"Sriwattanapong","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patcharaporn","family":"Gavila","sequence":"additional","affiliation":[{"name":"Department of Health, Intercountry Centre for Oral Health Ministry of Public Health  Mueang City Thailand"},{"name":"Geriatric Dentistry and Special Patients Care International Program, Chulalongkorn University Implant and Esthetic Center, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mawika","family":"Rinkrathok","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanokrat","family":"Sriwangyang","sequence":"additional","affiliation":[{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-531X","authenticated-orcid":false,"given":"Han Sung","family":"Jung","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry  Seoul 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