{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:15:00Z","timestamp":1790802900694,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis aimed to evaluate the most effective minimally invasive intra\u2010articular procedure for reducing pain and improving maximum mouth opening (MMO) in individuals diagnosed with painful articular TMD, specifically TMJ osteoarthritis and\/or internal derangement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Only randomized clinical trials (RCTs) assessing the efficacy of minimally invasive procedures, such as arthrocentesis and intra\u2010articular injection (IAI), were included. The meta\u2010analysis included seven studies with a 6\u2010month follow\u2010up, while 23 studies with different follow\u2010up periods were evaluated qualitatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The meta\u2010analysis showed that IAI with tenoxicam was the most effective procedure for pain reduction, with the highest [7.44 mean difference (MD); 6.28\u20138.60 confidence interval (CI)], followed by opioids (5.93; 5.03\u20136.83), the combination of hyaluronic acid (HA) with platelet\u2010rich plasma (PRP) (5.10; 4.52\u20135.68), and PRP alone (4.99; 3.13\u20136.85). For improvement in MMO, tenoxicam had the highest MD (+11.50\u2009mm; 15.47\u20137.53), followed by PRP (+10.46\u2009mm; 14.89\u20136.02) and the HA\u2010PRP combination (+10.10\u2009mm; 11.89\u20138.31).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tenoxicam showed promising results for pain reduction and improvement in MMO, although the evidence remains limited, followed by opioids and the combination of HA and PRP with arthrocentesis. Further high\u2010quality studies are needed to confirm their clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70284","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:10:37Z","timestamp":1773313837000},"page":"1828-1843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Intra\u2010Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Mateus Gaya","family":"dos Santos","sequence":"first","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas (UFPel)  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington Luiz de Oliveira","family":"da Rosa","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas (UFPel)  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