{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:11Z","timestamp":1777984211248,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ehlers\u2013Danlos syndromes are rare hereditary connective tissue disorders; however, their oral manifestations remain poorly characterized in molecularly confirmed individuals. The aim of this study was to describe the oral phenotype of patients with non\u2010vascular Ehlers\u2010Danlos syndromes compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center, cross\u2010sectional study, 14 patients molecularly diagnosed with non\u2010vascular Ehlers\u2010Danlos syndromes and 30 matched healthy controls underwent a complete clinical and radiological oral examination. Data were compared using chi\u2010squared, Fisher's exact, Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, or Wilcoxon tests as appropriate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to controls, patients with non\u2010vascular Ehlers\u2010Danlos syndromes had a significantly higher prevalence of temporomandibular disorders (64.3% vs. 16.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), gingivitis (85.7% vs. 56.7%; p\u2009=\u20090.017), and lingual parafunction (57.1% vs. 16.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Anatomical variations were also more frequent, including atrophy of the lingual (85.7% vs. 10.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and inferior labial frenula (78.6% vs. 20.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), pulpal retractions (61.5% vs. 27.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047), and dental root hypoplasia (57.1% vs. 20.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that patients with non\u2010vascular Ehlers\u2010Danlos syndromes present a distinct pattern with oral manifestations. These findings, including notably frenula atrophy and specific dental anomalies. These oral findings commonly observed in non\u2010vascular Ehlers\u2010Danlos syndromes patients can aid in diagnosis and underscore the need for specialized dental care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70294","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:15:11Z","timestamp":1773724511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Manifestations of Non Vascular Ehlers\u2010Danlos Syndrome Cross\u2010Sectional Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4324-1313","authenticated-orcid":false,"given":"Aude","family":"Grand","sequence":"first","affiliation":[{"name":"Health Faculty Paris Cit\u00e9 University  Paris \u00cele\u2010de\u2010France France"},{"name":"Oral Surgery Department, APHP Charles Foix Hospital  Ivry\u2010sur\u2010Seine France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin P. J.","family":"Fournier","sequence":"additional","affiliation":[{"name":"Paris Cit\u00e9 University and Sorbonne Paris Nord, INSERM, Sant\u00e9 Orale, Oral Health  Montrouge France"},{"name":"Reference Center of Oral and Dental Rare Diseases, H\u00f4pital Rothschild, APHP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9goire","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Health Faculty Paris Cit\u00e9 University  Paris \u00cele\u2010de\u2010France France"},{"name":"Periodontal Department, APHP Charles Foix Hospital  Ivry\u2010sur\u2010Seine France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karelle","family":"Benistan","sequence":"additional","affiliation":[{"name":"AP\u2010HP, GHU Paris Saclay CHU Raymond Poincar\u00e9, Reference Center for Non Vascular Ehlers\u2010Danlos Syndromes  Garches France"},{"name":"INSERM, UMR1179, University of Versailles Saint Quentin en Yvelines, UFR Simone Veil\u2010Sant\u00e9  Montigny\u2010le\u2010Bretonneux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois C\u00f4me","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Health Faculty Paris Cit\u00e9 University  Paris \u00cele\u2010de\u2010France France"},{"name":"Oral Surgery Department, APHP Charles Foix Hospital  Ivry\u2010sur\u2010Seine France"},{"name":"Paris Cit\u00e9 University and Sorbonne Paris Nord, INSERM, Sant\u00e9 Orale, Oral Health  Montrouge France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache Classification Committee of The International Headache Society (IHS) The International Classification of Headache Disorders, 3rd Edition","volume":"38","year":"2018","journal-title":"Cephalalgia: An International Journal of Headache"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20032218","article-title":"Oral Health\u2010Related Quality of Life in Different Subtypes of Ehlers\u2010Danlos Syndrome","volume":"20","author":"Balke J.","year":"2023","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"1","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O","article-title":"Ehlers\u2010Danlos Syndromes: Revised Nosology, Villefranche, 1997. 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