{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:29:45Z","timestamp":1777984185302,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170913"],"award-info":[{"award-number":["82170913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the distribution, lineage fate, and reparative function of Thy1 lineage cells in the mouse mandible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Single\u2010cell transcriptomic analysis was used to identify osteogenic subpopulations within mandibular mesenchymal stem cells. Lineage tracing in Thy1\u2010CreERT2;Rosa26\u2010tdTomato mice was employed to map the localization and osteogenic contribution of Thy1 lineage cells, while a critical\u2010sized mandibular defect model was established to assess their reparative dynamics. Loss\u2010 and gain\u2010of\u2010function experiments were performed using Thy1\u2010CreERT2;Rosa26\u2010DTR mice and transplantation of purified tdTomato\n                      <jats:sup>+<\/jats:sup>\n                      periosteal cells within hydrogel scaffolds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Single\u2010cell analysis identified a Thy1\u2010enriched osteoprogenitor subpopulation preferentially localized to the periosteum. Lineage tracing revealed that Thy1\u2010lineage cells constituted a major proportion of periosteal osteogenic cells and exhibited clonogenic expansion and ectopic bone formation. Following mandibular injury, tdTomato\n                      <jats:sup>+<\/jats:sup>\n                      cells progressively accumulated within the callus and represented the predominant osteogenic cell population at later stages. Genetic ablation of Thy1\u2010lineage cells markedly impaired bone repair, whereas transplantation of purified tdTomato\n                      <jats:sup>+<\/jats:sup>\n                      periosteal cells enhanced bone formation within the defect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thy1 lineage periosteal cells represent a functionally important osteoprogenitor population in mandibular bone regeneration, providing a cellular framework for future mechanistic and translational studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70309","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:51:32Z","timestamp":1776311492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thy1\n                    <sup>+<\/sup>\n                    Periosteal Osteoprogenitors Contribute to Mandibular Bone Defect Healing in Mice"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1132-8597","authenticated-orcid":false,"given":"Linmei","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji Research Institute of Stomatology &amp; Department of Prosthodontics, Shanghai Tongji Stomatological Hospital and Dental School Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji Research Institute of Stomatology &amp; Department of Prosthodontics, Shanghai Tongji Stomatological Hospital and Dental School Tongji University  Shanghai 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