{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:30:28Z","timestamp":1792773028325,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000106","name":"Saskatchewan Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The objective of this study was to investigate the global profile of plasmatic proteins of individuals affected simultaneously or not by type 2 diabetes mellitus (T2DM, well\/poorly\u2010controlled), Dyslipidemia (DL), and Periodontitis (P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Besides periodontal examination, plasma was collected for glycemic, and lipid analyses from 150 individuals divided into five groups. The same plasma was submitted to global proteomic investigation using the Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC\u2010ESI\u2010MS\/MS), following searching data in the UniProt catalog by Proteome Discoverer 1.3. Funcional enrichment was evaluated by Cytoscape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In groups (G1)T2DMpoorly\u2010DL\u2010P, (G2)T2DMwell\u2010DL\u2010P, and (G3)DL\u2010P, the presence of positively regulated CO4A (mediator of the inflammatory complement cascade) and TTN (sarcomeric protein linked to insulin\u2010dependent muscle stiffness) proteins was observed, similar to VDBP (vitamin D transporter and systemic inflammatory modulator) protein in groups (G2)T2DMwell\u2010DL\u2010P and (G3)DL\u2010P. Among others, LDLR, DST, SYNE1 (mediators of the lipid homeostasis axis and nuclear\u2010cytoskeletal integrity) and Ceruloplasmin (involved in iron metabolism and oxidative stress regulation) proteins were exclusively found in respective (G1)T2DMpoorly\u2010DL\u2010P, (G2)T2DMwell\u2010DL\u2010P, (G3)DL\u2010P and (G4)Perio groups. Functional enrichment analyses demonstrated complement binding, DNA metabolism and repair among the most up\u2010regulated PPI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Each of the combined pathological conditions exhibited a distinct plasmatic proteomic profile. This specificity provides a foundation for future studies to functionally characterize the identified upregulated proteins, both unique and shared. Our findings, therefore, contribute to the identification of potential diagnostic and therapeutic targets for each of these disease scenarios.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70313","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:41:52Z","timestamp":1775277712000},"page":"2465-2479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasmatic Profiling of Individuals With Combinations of Type 2 Diabetes Mellitus, Dyslipidemia and Periodontitis: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-2059","authenticated-orcid":false,"given":"Fran\u00e7ois Isnaldo Dias","family":"Caldeira","sequence":"first","affiliation":[{"name":"Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry at Araraquara UNESP\u2010S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"},{"name":"Department of Diagnosis and Surgery, School of Dentistry at Araraquara UNESP\u2010S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e2mia Cruz Tfaile","family":"Corbi","sequence":"additional","affiliation":[{"name":"Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry at Araraquara UNESP\u2010S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"},{"name":"Department of Diagnosis and Surgery, School of Dentistry at Araraquara UNESP\u2010S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alliny","family":"de Souza Bastos","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, School of Dentistry at Araraquara UNESP\u2010S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Regina Perez","family":"Orrico","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, School of Dentistry at Araraquara UNESP\u2010S\u00e3o Paulo State University  Araraquara S\u00e3o Paulo Brazil"},{"name":"Advanced Research Center in Medicine Union of the Colleges of the Great Lakes (UNILAGO)  S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Ribeiro","family":"Salmon","sequence":"additional","affiliation":[{"name":"Dental Research Division, School of Dentistry Paulista University  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Dentistry University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter 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