{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:35:37Z","timestamp":1775709337609,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Optimal wound healing is a primary objective in oral surgical procedures. This study evaluated the effects of chlorhexidine\u2009+\u2009anti\u2010discoloration system (CHX\u2009+\u2009ADS) with or without hyaluronic acid (HA) mouth rinse compared to placebo (PLCB) in promoting wound healing following third molar surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Healthy subjects with indication to third molar extraction were included in this single center, randomized, placebo\u2010controlled clinical trial. Following surgery, the patients were randomly assigned to three treatment groups, namely CHX\u2009+\u2009ADS + HA, CHX\u2009+\u2009ADS, or PLCB. Wound healing was assessed at 3, 7 and 14\u2009days postoperatively using the Early Healing Index (EHI) ranging between Score 1 (complete wound healing in the absence of fibrin line) and 5 (incomplete wound healing with necrotic tissue).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients (18 per group) were included in the analysis. At 3 and 7\u2009days, EHI scores were lower in both CHX\u2009+\u2009ADS\u2010 groups compared to PLCB (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 for CHX\u2009+\u2009ADS\u2009+\u2009HA,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for CHX\u2009+\u2009ADS). Improved healing at Days 3 and 7 was observed in the CHX\u2009+\u2009ADS\u2009+\u2009HA compared to CHX\u2009+\u2009ADS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). At 14\u2009days, no differences were noted among groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CHX\u2009+\u2009ADS\u2010based mouth rinses promoted early wound healing compared to placebo. The adjunct of HA improved wound closure, especially in the first postoperative week.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT05414253\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70317","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:35:24Z","timestamp":1775705724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Wound Healing After Chlorhexidine Rinsing in Third Molar Surgery: A Randomized Clinical Trial"],"prefix":"10.1111","author":[{"given":"Rossana","family":"Izzetti","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Priami","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Nisi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cinquini","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Barone","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Graziani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12432"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14030788"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01575.x"},{"issue":"9","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1600-051X.1984.tb00908.x","article-title":"Effect of Chlorhexidine Rinses on the Morphology of Early Dental Plaque Formed on Plastic Film","volume":"11","author":"Brecx M.","year":"1984","journal-title":"Journal of Clinical 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