{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:11Z","timestamp":1777984211212,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to clarify the association between periodontitis and prostate\u2010specific antigen and to guide the early prostate\u2010specific antigen screening of periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>1409 participants who visited West China Hospital of Sichuan University during 2021 and 2022 were included. Measurements were taken for blood pressure, fasting blood glucose, total cholesterol, triglycerides, C\u2010reactive protein, carcinoembryonic antigen, and prostate\u2010specific antigen. Participants went through periodontal examinations and were grouped into non\u2010periodontitis individuals, mild periodontitis, moderate periodontitis, and severe periodontitis. Logistic regression was used to explore the potential associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with severe periodontitis had significantly higher serum prostate\u2010specific antigen compared to non\u2010periodontitis individuals. No significant association between periodontitis and prostate\u2010specific antigen was found in participants aged 20\u201340. In patients aged 41\u201380, regression models showed a significant association between elevated prostate\u2010specific antigen and severe periodontitis, which was not significant in patients with mild and moderate periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In Chinese men aged 20\u201380\u2009years, serum prostate\u2010specific antigen was significantly higher in patients with severe periodontitis than in non\u2010periodontitis patients. Severe periodontitis was significantly associated with elevated PSA levels among elder patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70324","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:08:16Z","timestamp":1776402496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis Is Associated With Serum Prostate Specific Antigen Concentrations in\n                    <scp>C<\/scp>\n                    hinese Male"],"prefix":"10.1111","author":[{"given":"Yifei","family":"Long","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 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