{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:29:45Z","timestamp":1777984185335,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20252BAC200115"],"award-info":[{"award-number":["20252BAC200115"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460196"],"award-info":[{"award-number":["82460196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated the association between periodontitis, a chronic bacteria\u2010initiated inflammatory disease, and chronic obstructive pulmonary disease (COPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on the US National Health and Nutrition Examination Survey (NHANES) 2009\u20132014 data including 3626 adults aged 30\u201379, we analyzed the bidirectional association using multivariable binary logistic regression for periodontitis with COPD and ordinal regression for COPD with periodontitis severity. Besides, we compared systemic inflammation markers\u2014including neutrophil\u2010to\u2010lymphocyte (NLR), platelet\u2010to\u2010lymphocyte (PLR), and monocyte\u2010to\u2010lymphocyte ratios (MLR), alongside the systemic immune\u2010inflammation (SII) and aggregate systemic inflammation indices (AISI)\u2014among healthy control, periodontitis, and COPD groups using local clinical data from 210 subjects at the second affiliated hospital of Nanchang University.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After multivariable adjustment, individuals with mild\u2013moderate and severe periodontitis had 44% (OR\u2009=\u20091.44, 95% CI: 1.10\u20131.88) and 52% (OR\u2009=\u20091.52, 95% CI: 1.01\u20132.26) higher risks of COPD, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u2009=\u20090.007). Conversely, COPD was an independent risk factor for periodontitis severity (OR\u2009=\u20091.44, 95% CI: 1.14\u20131.82). Local data demonstrated that compared to healthy controls, AISI, SII, NLR, and MLR were significantly elevated in both periodontitis and COPD groups, while no significant difference was found between the two disease groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Periodontitis and COPD are both characterized by a similar systemic inflammatory profile and demonstrate a robust, independent, bidirectional association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70328","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:25:14Z","timestamp":1775705114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Periodontitis and\n                    <scp>COPD<\/scp>\n                    : A Large Multi\u2010Database Cross\u2010Sectional Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3584-8266","authenticated-orcid":false,"given":"Hongkai","family":"Zhang","sequence":"first","affiliation":[{"name":"Center of Stomatology, the Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"JXHC Key Laboratory of Periodontology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"The Institute of Periodontal Disease Nanchang University  Nanchang Jiangxi China"},{"name":"The Second Clinical Medical School Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-6337","authenticated-orcid":false,"given":"Guoping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Center of Stomatology, the Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"JXHC Key Laboratory of Periodontology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"The Institute of Periodontal Disease Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Hu","sequence":"additional","affiliation":[{"name":"Center of Stomatology, the Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"JXHC Key Laboratory of Periodontology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"The Institute of Periodontal Disease Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Dai","sequence":"additional","affiliation":[{"name":"Center of Stomatology, the Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"JXHC Key Laboratory of Periodontology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"The Institute of Periodontal Disease Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"Center of Stomatology, the Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"JXHC Key Laboratory of Periodontology The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"The Institute of Periodontal Disease Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010017\u20100577\u2010y"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519846113"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21\u20100399"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2021.120652"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052612"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169104"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(12)70060\u20107"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13228"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1377792"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2023.11.022"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120399"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010025\u201001975\u2010y"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004635\u20106"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1285509"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340010"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.50"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.251"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20127"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161118666200130093432"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519833630"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2530792"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13949"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S233834"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S393323"},{"key":"e_1_2_13_27_1","volume-title":"The Fourth National Oral Health Epidemiological Survey Report","author":"Wang X.","year":"2018"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00572\u201023"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S425172"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102022\u2010067432"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110786"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010024\u201003025\u20106"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1612199"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70328","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:25:20Z","timestamp":1775705120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":32,"alternative-id":["10.1111\/odi.70328"],"URL":"https:\/\/doi.org\/10.1111\/odi.70328","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.70328\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.70328\/v1\/review1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"odi.70328"}}