{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:22:25Z","timestamp":1793146945098,"version":"4.5.0"},"reference-count":85,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS 2026\u201025483834"],"award-info":[{"award-number":["RS 2026\u201025483834"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non\u2010erosive subtype (NEOLP) through transcriptomic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed bulk RNA\u2010seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA), transcription factor inference, bulk transcriptome deconvolution with xCell 2.0, metabolic flux simulation and novel pathway correlation analysis combining Gene Set Variation Analysis (GSVA) with Differential Gene Correlation Analysis (DGCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three molecular signatures distinguished EOLP from NEOLP. First, metabolic\u2013inflammatory coordination was disrupted in EOLP, with reversed correlations between integrated stress response regulators and metabolic pathways. Second, EOLP showed concurrent suppression of cell cycle and senescence programs, suggesting an altered epithelial state. Third, inflammatory profiling revealed myeloid\u2010skewed activation (elevated SPI1\/PU.1), enrichment of bacterial\u2010response pathways, and loss of epithelial barrier signatures (GRHL2, keratinization). Mitochondrial dysfunction with selective Complex IV upregulation further supported a myeloid\u2010driven metabolic remodelling in EOLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EOLP is characterised by disrupted metabolic\u2013stress coordination, epithelial dysregulation, and myeloid\u2010dominant inflammation. Our findings support a model in which microbial\u2010associated stimuli may drive myeloid\u2010centred metabolic reprogramming that sustains chronic inflammatory activity in EOLP. These results highlight potential therapeutic axes including restoration of metabolic\u2013inflammatory balance, modulation of microbial influences, and epithelial barrier repair, although validation in larger cohorts and higher\u2010resolution studies is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70332","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:51:01Z","timestamp":1784623861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non\u2010Erosive Oral Lichen Planus"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9216-7421","authenticated-orcid":false,"given":"Kisung","family":"Sheen","sequence":"first","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center, Clinical Research Institute Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Biomedical Science and Technology Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaerim","family":"Song","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center, Clinical Research Institute Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Biomedical Informatics Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanghyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center, Clinical Research Institute Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center, Clinical Research Institute Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine  Seoul Republic of Korea"},{"name":"School of Dentistry Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6918-1562","authenticated-orcid":false,"given":"Hye\u2010Ji","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Kyung Hee University Dental Hospital at Gangdong  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-9829","authenticated-orcid":false,"given":"Man S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center, Clinical Research Institute Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Biomedical Science and Technology Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-023-01763-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.391330"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-025-03784-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbac016"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199602)166:2<281::AID-JCP5>3.0.CO;2-L"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.04.009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1238774"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01516.x"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"61","article-title":"The Topical Treatment of Atrophic\u2010Erosive Oral Lichen Planus With Fluocinonide in a Bioadhesive Gel, Chlorhexidine and Miconazole Gel. 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