{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:59:03Z","timestamp":1788303543431,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the adjunctive efficacy of a hyaluronic acid (HA) gel with 0.20% chlorhexidine (CHX) during nonsurgical periodontal therapy in periodontal patients over 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010blind, randomized, controlled trial included 40 healthy, nonsmoking adults with periodontitis. After supra\u2010 and subgingival debridement, patients used either HA gel (Aftoral; hyaluronic acid with glycerophosphoinositol and xylitol) or CHX mouthwash (Unidea; 0.20% chlorhexidine digluconate) once daily for 15\u2009days at each time recall appointment. Clinical parameters\u2014probing pocket depth (PPD, primary outcome), plaque control record (PCR), bleeding on probing (BoP), gingival recession (GR), tooth mobility (TM), clinical attachment level (CAL), and satisfaction (VAS)\u2014were measured at baseline, 1, 3, and 6\u2009months by a blinded examiner. Nonparametric tests were applied with significance at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HA showed greater PPD reduction than CHX at 3 and 6\u2009months (\u22120.44\u2009mm vs. \u22120.26\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). PCR and BoP decreased more in the HA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while CAL gain was higher (\u22120.43\u2009mm vs. \u22120.21\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). GR, TM, and VAS showed no differences. No adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjunctive HA gel improved PPD, PCR, BoP, and CAL compared with CHX, confirming safety, and clinical benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70345","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:50:08Z","timestamp":1776311408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of a Hyaluronic Acid\u2010Based Gel Versus 0.20% Chlorhexidine in Nonsurgical Periodontal Therapy: A\u00a0Single\u2010Blind Randomized Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-0124","authenticated-orcid":false,"given":"Andrea","family":"Scribante","sequence":"first","affiliation":[{"name":"Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"},{"name":"Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1690-4904","authenticated-orcid":false,"given":"Maurizio","family":"Pascadopoli","sequence":"additional","affiliation":[{"name":"Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-5398","authenticated-orcid":false,"given":"Matteo","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyna","family":"Chekal","sequence":"additional","affiliation":[{"name":"Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-4415","authenticated-orcid":false,"given":"Andrea","family":"Butera","sequence":"additional","affiliation":[{"name":"Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCIDE.S316838"},{"issue":"3","key":"e_1_2_13_3_1","first-page":"1","article-title":"Evaluation of 0.8% Hyaluronic Acid as an Adjunctive to Non\u2010Surgical Periodontal Therapy in Chronic Periodontitis: A Randomized Clinical Study","volume":"32","author":"Abdulkareem A.","year":"2020","journal-title":"Journal of Baghdad College of Dentistry"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-06485-2"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/18742106-v17-e230510-2022-115"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15071883"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010031\u201079146\u20108_16"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05906-w"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/ijod\/6655743"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05505-9"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2022.1574"},{"issue":"2","key":"e_1_2_13_12_1","first-page":"161","article-title":"Side Effects of 0.2% Chlorhexidine Mouthrinse Used in a General Dental Practice","volume":"63","author":"Burns J.","year":"1997","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj12040116"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2011.01732.x"},{"issue":"1","key":"e_1_2_13_15_1","first-page":"S1","article-title":"A New Classification Scheme for Periodontal and Peri\u2010Implant Diseases and Conditions","volume":"89","author":"Caton J. 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