{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:01:53Z","timestamp":1781157713097,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sialolithiasis pathophysiology is multifactorial, with systemic medications often hypothesised as a key contributor, particularly in older adults (Drug\u2010Induced Sialolithiasis). However, robust evidence supporting this theory is limited. This study aimed to investigate the association between common medication classes and sialolithiasis in an older Israeli cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A nationwide retrospective case\u2013control study (2005\u20132024) was conducted using the Clalit Health Services database. Sialolithiasis cases were matched 1:3 with controls based on age and gender. After stratification using a Gaussian Mixture Model (age\u2009&gt;\u200950.28\u2009years), logistic regression analyses assessed the association between sialolithiasis and antihyperlipidemic, antihypertensive, psychiatric, neurologic and antidiabetic medications. Significance was considered under\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 32,088 individuals (8015 cases). Multivariable analysis revealed significantly increased odds of sialolithiasis associated with neurologic (OR 1.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), antihyperlipidemic (OR 1.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), psychiatric (OR 1.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and antihypertensive medications (OR 1.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). Antidiabetics showed no significant association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This large\u2010scale analysis strongly supports the theory of Drug\u2010Induced Sialolithiasis. The independent association between these four common medication classes and increased odds of sialolithiasis in older adults suggests that medication\u2010induced hyposalivation is a major, quantifiable risk factor in the aetiology of the condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70366","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:55:01Z","timestamp":1781157301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Induced Sialolithiasis\u2014A Big\u2010Data Retrospective Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5111-8496","authenticated-orcid":false,"given":"Gal","family":"Avishai","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Centre  Petach\u2010Tikva Israel"},{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Caspi","sequence":"additional","affiliation":[{"name":"Faculty of Electrical and Computer Engineering Technion \u2013 Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-9512","authenticated-orcid":false,"given":"Akhilanand","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology King George's Medical University  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-4978","authenticated-orcid":false,"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Centre  Petach\u2010Tikva Israel"},{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3808-8664","authenticated-orcid":false,"given":"Daya","family":"Masri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Centre  Petach\u2010Tikva Israel"},{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Jonas","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Centre  Petach\u2010Tikva Israel"},{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164110390243"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010020\u201003750\u20102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.37358\/RC.17.10.5902"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.37358\/RC.18.6.6374"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010020\u201003318\u20100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924\u2010977X(16)31576\u20100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2020.00019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201051013\u20103"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.3.1750829"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010020\u201008674\u2010w"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010025\u201006179\u20107"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13369"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15095"},{"issue":"6","key":"e_1_2_11_15_1","first-page":"619","article-title":"Saliva 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