{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:58:43Z","timestamp":1780905523926,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) preconditioned with low\u2010magnitude high\u2010frequency (LMHF) vibration on temporomandibular joint osteoarthritis (TMJOA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BMSCs with\/without LMHF vibration were intra\u2010articularly injected into TMJOA model rats. After 8\u2009weeks, joint diameter was measured. Pathological alterations were observed through histological staining techniques (CXCR4, SOX9). In\u00a0vitro, BMSCs and chondrocytes were co\u2010cultured with LMHF vibration. Chondrocyte proliferation was assessed by CCK\u20108. In a tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1)\u2010induced inflammatory microenvironment, signal transduction\u2010related and autophagy\u2010related proteins were detected by quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) and Western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The injection of LMHF vibrated BMSCs increases the joint diameter and alleviates TMJ tissue damage. The OA model led to an elevation in CXCR4 levels and a reduction in SOX9 in condyle cartilage, while vibrated BMSCs upregulated both. In\u00a0vitro experiments, appropriate cyclic sinusoidal dynamic mechanical vibration enhanced the proliferative capacity of chondrocytes co\u2010cultured with BMSCs. In inflammation, the vibration group downregulated chondrocyte MMP\u201013 and upregulated chondrocyte Collagen II\/BMP7\/\u03b2\u2010catenin\/Atg3, as well as BMSC Collagen X\/BMP7\/\u03b2\u2010catenin\/CXCR4\/Beclin\u20101\/Atg5\u2014all protein levels exceeded those in the LiCl group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For cartilage tissue engineering, LMHF vibration serves as a promising strategy to rapidly expand cells with a reinforced chondrogenic phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70378","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T07:21:15Z","timestamp":1780903275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Effects of\n                    <scp>BMSCs<\/scp>\n                    Stimulated by Low\u2010Magnitude High\u2010Frequency Vibration on\n                    <scp>TMJOA<\/scp>"],"prefix":"10.1111","author":[{"given":"Weiwei","family":"Hou","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang University School of Medicine  Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang University School of Medicine  Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-6420","authenticated-orcid":false,"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10857"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.036293"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30086"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.152504"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.062"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2757"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505259102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5979741"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013\u20100207"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.04.011"},{"key":"e_1_2_11_12_1","volume-title":"The Effects of Mechanical Vibration on Human Chondrocytes In\u00a0Vitro. 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