{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:05:24Z","timestamp":1783922724828,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406291\/2021\u20107"],"award-info":[{"award-number":["406291\/2021\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["408830\/2024\u20107"],"award-info":[{"award-number":["408830\/2024\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of prophylactic photobiomodulation therapy (PBMT) in preventing oral mucositis (OM) and to assess serum and salivary methotrexate (MTX) levels as predictors of OM in adults receiving high\u2010dose methotrexate (HD\u2010MTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This phase II randomized, double\u2010blind, placebo\u2010controlled trial enrolled adults with hematological malignancies undergoing a first HD\u2010MTX cycle at a tertiary cancer center in Brazil. Participants were randomized to PBMT or sham laser therapy, administered daily until MTX clearance or for up to five sessions. OM was assessed for 9\u2009days using WHO criteria. Serum and salivary MTX concentrations were measured at 24, 48, and 72\u2009h post\u2010infusion, along with urinary pH and serum creatinine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010three patients were randomized (PBMT\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926; placebo\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927). PBMT significantly reduced ulcerative OM (grade \u2265\u20092) at 96\u2009h (11.5% vs. 51.9%), yielding a 77.7% relative risk reduction and a number needed to treat of 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Placebo recipients had an 8.97\u2010fold higher odds of severe OM. Serum MTX was not associated with OM, whereas salivary MTX increased disproportionately over time and independently correlated with OM severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PBMT significantly reduced OM incidence and severity in adults receiving HD\u2010MTX. Salivary MTX is a promising non\u2010invasive biomarker for OM risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Trial was prospectively registered in the Brazilian Registry of Clinical Trials (ReBec, No. 12218)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70381","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:12:23Z","timestamp":1783919543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Methotrexate as a Predictor of Oral Mucositis in Hematological Cancer Patients: A Phase II Randomized, Double\u2010Blind Clinical Trial"],"prefix":"10.1111","author":[{"given":"Let\u00edcia","family":"Rodrigues\u2010Oliveira","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department, Faculdade de Odontologia de Piracicaba 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