{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:52:39Z","timestamp":1788292359712,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate intraoral\u2010ultrasound (ioUS) features of benign and malignant oral lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cross\u2010sectional study, patients with oral soft tissue lesions underwent ioUS followed by biopsy within 2\u2009weeks. Sonographic features: size, echogenicity, cystic areas, calcifications, margins, and vascularity were compared with histopathology. Associations between sonographic features and malignancy were explored using univariate and multivariable analyses. ROC analysis was used descriptively to explore discriminatory ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010one patients with 52 lesions (24 females, 27 males; mean age 60.1\u2009\u00b1\u200916.7\u2009years, range 18\u201390) were recruited. Following exclusions, the study comprised 23 histologically confirmed malignant cases (squamous cell carcinoma, SCC) and 23 benign cases. Multivariate analysis identified maximal diameter (&gt;\u200912\u2009mm; sensitivity 0.76 [95% CI: 0.53\u20130.90], specificity 0.77 [95% CI: 0.57\u20130.90]), ill\u2010defined margins (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and increased vascularity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) as being associated with SCC in this cohort. Combinations of these features showed high apparent discrimination (AUC 0.92 [95% CI: 0.84\u20131.00]), but likely reflect optimistic bias given the small sample size and lack of validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pilot study describes ioUS features in benign and malignant oral lesions and identifies sonographic features potentially associated with malignancy. These findings are exploratory and hypothesis\u2010generating and require validation in larger, more diverse cohorts before any clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70395","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:38:02Z","timestamp":1781843882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pre\u2010Operative Intraoral Ultrasound Features of Benign and Malignant Oral Lesions: An Exploratory Pilot Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-1512","authenticated-orcid":false,"given":"Ragda","family":"Abdalla\u2010Aslan","sequence":"first","affiliation":[{"name":"Rappaport Faculty of Medicine Technion Israel Institute of Technology  Haifa Israel"},{"name":"The Department of Oral and Maxillofacial Surgery Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Gaitini","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion Israel Institute of Technology  Haifa Israel"},{"name":"The Department of Medical Imaging Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Rachmiel","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion Israel Institute of Technology  Haifa Israel"},{"name":"The Department of Oral and Maxillofacial Surgery Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goni","family":"Merhav","sequence":"additional","affiliation":[{"name":"The Department of Medical Imaging Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Akrish","sequence":"additional","affiliation":[{"name":"The Department of Oral and Maxillofacial Surgery Rambam Health Care Campus  Haifa Israel"},{"name":"The Department of Pathology Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Javitt","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Department of Radiology Mount Sinai Medical Center  Miami Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekel","family":"Shilo","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion Israel Institute of Technology  Haifa Israel"},{"name":"The Department of Oral and Maxillofacial Surgery Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omri","family":"Emodi","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion Israel Institute of Technology  Haifa Israel"},{"name":"The Department of Oral and Maxillofacial Surgery Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotam","family":"Shkedy","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion Israel Institute of Technology  Haifa Israel"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Beck\u2010Razi","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion Israel Institute of Technology  Haifa Israel"},{"name":"The Department of Medical Imaging Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","first-page":"352","article-title":"Intraoral and Transcutaneous Point\u2010Of\u2010Care\u2010Ultrasound: An Adjunct Bedside Tool for Oral and Maxillofacial Clinicians","volume":"53","author":"Abdalla\u2010Aslan R.","year":"2022","journal-title":"Quintessence International"},{"key":"e_1_2_12_3_1","article-title":"Oral Soft\u2010Tissue Biopsy: An Overview","volume":"78","author":"Avon S. 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