{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:05:46Z","timestamp":1783915546916,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271008"],"award-info":[{"award-number":["82271008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571128"],"award-info":[{"award-number":["82571128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501200"],"award-info":[{"award-number":["82501200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The nervous system plays a crucial role in regulating bone remodeling, with both sensory and autonomic nerves distributed within bone tissue. In the mandible, the inferior alveolar nerve (IAN) and sympathetic nerves provide the primary innervation. Numerous studies have demonstrated their essential functions in mandibular development and bone metabolism. Focusing on mandibular innervation, we synthesize current evidence to demonstrate the modulatory effects of sensory and sympathetic nerves on bone growth and regeneration, and further elucidate the underlying mechanisms. Notably, we discuss multiple bioactive factors (CGRP, SP, VIP, NE, NPY, Sema3A, NGF) for their roles in mediating neural regulation of bone. Additionally, neuro\u2010bone crosstalk in the mandible is examined in an integrated way. This review offers a deeper understanding of mandibular homeostasis modulated by nerves and thus seeks to facilitate future clinical translation.<\/jats:p>","DOI":"10.1111\/odi.70406","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:55:38Z","timestamp":1783914938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Sensory and Sympathetic Nerves in the Development and Bone Metabolism of Mandible"],"prefix":"10.1111","author":[{"given":"Zhiyi","family":"Zhao","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifei","family":"Tian","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University  Hangzhou 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