{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:30:25Z","timestamp":1792773025027,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002467","name":"Dankook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002467","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of sequential administration of romosozumab and denosumab on post\u2010extraction socket healing and osteonecrosis development in a murine tooth extraction model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty female mice were randomly assigned to four groups: control (Ctrl), romosozumab (Rm), denosumab (Dmab), and sequential romosozumab followed by denosumab (Rm\u2009+\u2009Dmab). After drug administration, bilateral maxillary first molars were extracted. Extraction socket healing was evaluated by micro\u2010computed tomography, histological analysis, and immunohistochemistry for receptor activator of nuclear factor \u03baB ligand (RANKL), osteoprotegerin (OPG), and sclerostin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Rm\u2009+\u2009Dmab group exhibited significantly less new bone formation and more necrotic bone in the extraction sockets than the other groups, accompanied by a marked reduction in osteoclast numbers. The Dmab\u2010only group showed a lower RANKL\/OPG ratio. No significant differences in sclerostin expression were observed among groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sequential administration of romosozumab followed by denosumab severely impaired extraction socket healing and induced osteonecrotic lesions in mice, resembling medication\u2010related osteonecrosis of the jaw (MRONJ). These findings suggest that such sequential antiresorptive therapy may increase the risk of MRONJ in patients undergoing dental extractions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70417","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:46:46Z","timestamp":1784519206000},"page":"2402-2411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Anabolic and Antiresorptive Treatment Promotes Medication\u2010Related Osteonecrosis of the Jaw in Mice"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5042-1658","authenticated-orcid":false,"given":"Seo\u2010Yeong","family":"An","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery College of Dentistry, Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae\u2010Seo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery College of Dentistry, Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5635-7728","authenticated-orcid":false,"given":"Reuben H.","family":"Kim","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research  Los Angeles California USA"},{"name":"UCLA Jonsson Comprehensive Cancer Centre  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery College of Dentistry, Dankook University  Cheonan Republic of 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