{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:01:09Z","timestamp":1785308469492,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral potentially malignant disorders (OPMDs) are clinically significant lesions associated with malignant change, while malignant lesions represent established disease. Histopathological evaluation plays a key role in diagnosis within hospital\u2010based biopsy services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinicopathological characteristics and anatomical distribution of oral malignant lesions and OPMDs in a tertiary care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross\u2010sectional hospital\u2010based case series included 1096 patients who underwent oral biopsy between 2020 and 2025. Only biopsy\u2010confirmed malignant lesions and OPMDs were included, whereas benign oral lesions were excluded. Demographic, anatomical, biopsy, and histopathological data were analyzed using descriptive statistics and chi\u2010square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Males comprised 56.6% and females 43.4% of cases, with the highest lesion frequency in the 51\u201360\u2010year age group (28.5%). Within this selected biopsy cohort, malignant lesions accounted for 64.8% and OPMDs for 35.2%. OSCC was the most common malignant lesion (44.9%), followed by verrucous carcinoma (23.2%). Leukoplakia with dysplasia (50.3%) and oral submucous fibrosis (27.2%) were the most frequent OPMDs. Buccal mucosa predominated in malignant lesions, whereas OPMDs were more common on the tongue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This retrospective hospital\u2010based case series provides descriptive clinicopathological insights into oral malignant lesions and OPMDs within a tertiary referral setting. Findings reflect a selected biopsy population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70429","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:05:15Z","timestamp":1785305115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Characteristics of Oral Malignant Lesions and Oral Potentially Malignant Disorders: A Retrospective Hospital\u2010Based Case Series"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-2399","authenticated-orcid":false,"given":"Fatema","family":"Akhter","sequence":"first","affiliation":[{"name":"College of Dentistry Dar Al Uloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-9656","authenticated-orcid":false,"given":"Nourelhoda","family":"Alim","sequence":"additional","affiliation":[{"name":"College of Dentistry Dar Al Uloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-3815","authenticated-orcid":false,"given":"Tahsinul","family":"Haque","sequence":"additional","affiliation":[{"name":"College of Dentistry Dar Al Uloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Saad","family":"Alqarni","sequence":"additional","affiliation":[{"name":"College of Dentistry Al Jouf University  Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"AlAkkam","sequence":"additional","affiliation":[{"name":"College of Dentistry Dar Al Uloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alshammari","sequence":"additional","affiliation":[{"name":"College of Dentistry Prince Sattam Bin Abdulaziz University  Alkharj Saudi 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