{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:06:28Z","timestamp":1784264788510,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate (i) the presence of red complex bacteria in carotid atheroma plaques of dentate and edentulous patients and (ii) the possible relationship between mitochondrial DNA copy number (mtDNA\u2010cn), an indicator of mitochondrial function, and periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study included 51 patients (30 dentate and 21 edentulous) scheduled for carotid endarterectomy. Subgingival, denture and atheroma plaques were analysed using polymerase chain reaction (PCR) for red complex bacteria. Atheroma plaque samples from all patients were examined using quantitative PCR for mtDNA\u2010cn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At least one bacterium was detected in both the subgingival and denture plaque. In the dentate group, the frequencies of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Tannerella forsythia<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Treponema denticola<\/jats:italic>\n                      <\/jats:styled-content>\n                      in atheroma plaques were 53.3%, 63.3% and 40%, respectively. In the edentulous group, these rates were 57.1%, 23.8% and 42.9%, respectively. The mtDNA\u2010cn in atheroma plaque samples from the dentate group was significantly lower than that in edentulous patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that red complex bacteria can be present in atheroma plaques, even in long\u2010standing edentulous patients. Our findings suggest that existing periodontal infection in patients with teeth may be associated with decreased mtDNA\u2010cn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      NCT07165054 (registration date: 09\/03\/2025):\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT07165054?term=ay%C5%9Fe%20toraman&amp;rank=5\">https:\/\/clinicaltrials.gov\/study\/NCT07165054?term=ay%C5%9Fe%20toraman&amp;rank=5<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70431","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:37:29Z","timestamp":1784263049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Red\u2010Complex Bacterial\n                    <scp>DNA<\/scp>\n                    in Carotid Atheroma of Dentate and Long\u2010Term Edentulous Patients and Its Association With Mitochondrial\n                    <scp>DNA<\/scp>\n                    Copy Number"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-0765","authenticated-orcid":false,"given":"Ay\u015fe","family":"Toraman","sequence":"first","affiliation":[{"name":"Hamidiye Faculty of Dentistry, Department of Periodontology Health Sciences University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-8085","authenticated-orcid":false,"given":"Ebru","family":"Sa\u011flam","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medeniyet University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Toraman","sequence":"additional","affiliation":[{"name":"Science Faculty, Department of Molecular Biology and Genetics Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Ketenciler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Istanbul Prof. Dr. Cemil Tascioglu City Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"K\u00f6seo\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medeniyet University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1203","article-title":"Keratoconus Is Associated With Increased Copy Number of Mitochondrial DNA","volume":"20","author":"Abu\u2010Amero K. 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