{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:07:25Z","timestamp":1785139645486,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of oral squamous cell carcinoma (OSCC) in younger patients is increasing, but it remains unclear whether early\u2010onset disease differs prognostically from OSCC in older individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively compared 68 patients aged \u2264\u200945\u2009years and 616 patients aged &gt;\u200945\u2009years with primary surgically treated OSCC (2009\u20132021). Clinicopathological variables were reassessed according to the eighth edition of the UICC\/AJCC TNM classification. Overall survival (OS) and locoregional recurrence\u2010free survival (LRRFS) were analyzed using Kaplan\u2013Meier and log\u2010rank methods; cohorts were compared using chi\u2010square and Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five\u2010year OS and LRRFS were similar in younger and older patients (77%\/74% vs. 74%\/74%). In both cohorts, outcomes were significantly associated with tumor stage, nodal status, resection margins, lymph node ratio (LNR), and histopathological risk factors including perineural and lymphovascular invasion. Among node\u2010positive patients, higher LNR was associated with worse OS in both age groups, while older patients showed significantly higher LNR values despite comparable lymph node metastasis rates. Tumor localization differed significantly: tongue carcinomas were more frequent in younger patients, whereas floor\u2010of\u2010mouth and mandibular tumors predominated in older individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In surgically treated OSCC, prognosis appears to be determined primarily by tumor\u2010related factors rather than patient age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70432","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:24:59Z","timestamp":1784049899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Characteristics and Survival in Young Adults With Oral Squamous Cell Carcinoma: A\u00a0Retrospective Comparative Cohort Study"],"prefix":"10.1111","author":[{"given":"Jeanne Christine","family":"Eitner\u2010Pchalek","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery and Interdisciplinary, Department of Oral Surgery and Implantology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery and Interdisciplinary, Department of Oral Surgery and Implantology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Linz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery and Interdisciplinary, Department of Oral Surgery and Implantology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-7457","authenticated-orcid":false,"given":"Matthias","family":"Kreppel","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery and Interdisciplinary, Department of Oral Surgery and Implantology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_16_18"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13213339"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.11.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2020.03.009"},{"issue":"6","key":"e_1_2_12_6_1","first-page":"e679","article-title":"Oral and Oropharyngeal Squamous Cell Carcinoma in 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