{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T04:03:23Z","timestamp":1784520203590,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301026"],"award-info":[{"award-number":["82301026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Medication\u2010related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive or antiangiogenic therapy, yet its molecular mechanisms remain poorly understood. This study aimed to identify potential core genes involved in MRONJ pathogenesis through integrative bioinformatics analysis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n GSE7116 dataset (PBMC samples from 11 MRONJ and 10 non\u2010MRONJ multiple myeloma patients on bisphosphonates) was analyzed. DEGs were identified using GEO2R. Functional enrichment, PPI network, hub gene identification, ROC\u2010based diagnostic evaluation, and independent qRT\u2010PCR validation were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 241 DEGs (212 down, 29 up) were identified, enriched in immune\/inflammatory responses and NOD\u2010like receptor\/NF\u2010\u03baB pathways. Ten hub genes (\n TNF<\/jats:italic>\n ,\n ACTB<\/jats:italic>\n ,\n IL1B<\/jats:italic>\n ,\n JUN<\/jats:italic>\n ,\n CXCL8<\/jats:italic>\n ,\n CXCR4<\/jats:italic>\n ,\n PTPRC<\/jats:italic>\n ,\n IL1A<\/jats:italic>\n ,\n HSP90AB1<\/jats:italic>\n ,\n RHOA<\/jats:italic>\n ) were identified. Four of them (\n HSP90AB1<\/jats:italic>\n ,\n RHOA<\/jats:italic>\n ,\n CXCL8<\/jats:italic>\n ,\n IL1B<\/jats:italic>\n ) showed high diagnostic accuracy (AUC 0.864\u20130.936) and were validated by qRT\u2010PCR.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This integrative bioinformatics analysis, combined with ROC evaluation and experimental qPCR validation, identifies immune\u2010 and inflammation\u2010related hub genes as central to MRONJ pathogenesis. A four\u2010gene signature (\n HSP90AB1<\/jats:italic>\n ,\n RHOA<\/jats:italic>\n ,\n CXCL8<\/jats:italic>\n ,\n IL1B<\/jats:italic>\n ) shows high diagnostic accuracy (AUC 0.864\u20130.936) and is proposed as a peripheral blood\u2010based diagnostic panel. The widespread downregulation of inflammatory genes in PBMCs suggests systemic immunosuppression rather than overt inflammation, offering new insights for immunomodulatory strategies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.70438","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:41:02Z","timestamp":1784518862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Potential Core Genes in Medication\u2010Related Osteonecrosis of the Jaw via Bioinformatics Analysis"],"prefix":"10.1111","author":[{"given":"Xinliang","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Gu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"},{"name":"Department of Endodontics Stomatology Hospital of Jilin University, Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u2010Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology University of Oslo and Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-3331","authenticated-orcid":false,"given":"Zilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","article-title":"Medication\u2010Related Osteonecrosis of the Jaw: A Review","volume":"12","author":"Aldhalaan N. A.","year":"2020","journal-title":"Cureus"},{"issue":"6","key":"e_1_2_13_3_1","article-title":"Identified Medications Causing Medication\u2010Related Osteonecrosis of the Jaw: A Literature Review","volume":"17","author":"Baghalipour N.","year":"2025","journal-title":"Cureus Journal of Medical Science"},{"issue":"12","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jormas.2024.101931","article-title":"Epidemiology, Etiopathogenesis, and Management of Mronj: A European Multicenter Study","volume":"125","author":"Boffano P.","year":"2024","journal-title":"Journal of Stomatology, Oral and Maxillofacial Surgery"},{"issue":"2","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.2287","article-title":"TNF\u2010Mediated Inflammatory Disease","volume":"214","author":"Bradley J. R.","year":"2008","journal-title":"Journal of Pathology"},{"issue":"2","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1200\/JCO.24.00171","article-title":"Incidence of Medication\u2010Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20\u2010Year Follow\u2010Up: A Population\u2010Based Multicenter Retrospective Study","volume":"43","author":"Brunner C.","year":"2025","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/978-3-032-03176-1_20","article-title":"Infectious\/Inflammatory Oral Diseases and Medication\u2010Related Osteonecrosis of the Jaw (MRONJ)","volume":"1492","author":"Cintra L. T. A.","year":"2026","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"8","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.4049\/jimmunol.1203266","article-title":"Cxcl8 (IL\u20108) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response","volume":"190","author":"De Oliveira S.","year":"2013","journal-title":"Journal of Immunology"},{"issue":"1","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202500627","article-title":"Progress in Research on Medication\u2010Related Osteonecrosis of the Jaw: From Pathophysiological Mechanisms to Clinical Treatment","volume":"10","author":"Duan X.","year":"2026","journal-title":"Advanced Biology"},{"issue":"9","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13092679","article-title":"Osteonecrosis of the Jaw Associated With Bisphosphonates Infusion for Treatment of Plasma Cell Myeloma\u2010A Retrospective Observational Study of Northern Portuguese Population","volume":"13","author":"Ferreira S. S.","year":"2024","journal-title":"Journal of Clinical Medicine"},{"issue":"1","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41368-020-00093-2","article-title":"Pathogenesis and Multidisciplinary Management of Medication\u2010Related Osteonecrosis of the Jaw","volume":"12","author":"He L.","year":"2020","journal-title":"International Journal of Oral Science"},{"issue":"1","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1365-2249.2005.02665.x","article-title":"The Bisphosphonate Acute Phase Response: Rapid and Copious Production of Proinflammatory Cytokines by Peripheral Blood Gd T Cells in Response to Aminobisphosphonates Is Inhibited by Statins","volume":"139","author":"Hewitt R. E.","year":"2005","journal-title":"Clinical and Experimental Immunology"},{"issue":"4","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/jbmr.1769","article-title":"Can Peripheral Blood \u03b3\u03b4 T Cells Predict Osteonecrosis of the Jaw? An Immunological Perspective on the Adverse Drug Effects of Aminobisphosphonate Therapy","volume":"28","author":"Kalyan S.","year":"2013","journal-title":"Journal of Bone and Mineral Research"},{"issue":"4","key":"e_1_2_13_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101131","article-title":"The Receptor\u2010Type Protein Tyrosine Phosphatase Cd45 Promotes Onset and Severity of IL\u20101\u03b2\u2010Mediated Autoinflammatory Osteomyelitis","volume":"297","author":"Kralova J.","year":"2021","journal-title":"Journal of Biological Chemistry"},{"issue":"24","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262411788","article-title":"Integrative Transcriptomic and Machine\u2010Learning Analysis Reveals Immune\u2010Inflammatory and Stress\u2010Response Alterations in MRONJ","volume":"26","author":"Laputkov\u00e1 G.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"issue":"23","key":"e_1_2_13_16_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316745","article-title":"Medication\u2010Related Osteonecrosis of the Jaw: A Systematic Review and a Bioinformatic Analysis","volume":"24","author":"Laputkov\u00e1 G.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_13_17_1","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.2147\/OTT.S166567","article-title":"Identification of Potential Core Genes in Triple Negative Breast Cancer Using Bioinformatics Analysis","volume":"11","author":"Li M. X.","year":"2018","journal-title":"Oncotargets and Therapy"},{"issue":"35","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.2174\/138161210794455003","article-title":"Cxcl12\u2010Cxcr4 Axis in Angiogenesis, Metastasis and Stem Cell Mobilization","volume":"16","author":"Liekens S.","year":"2010","journal-title":"Current Pharmaceutical Design"},{"issue":"5","key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1111\/odi.14201","article-title":"Quantitative Proteomics in Medication\u2010Related Osteonecrosis of the Jaw: A Proof\u2010Of\u2010Concept Study","volume":"29","author":"Lorenzo\u2010Pouso A. I.","year":"2023","journal-title":"Oral Diseases"},{"key":"e_1_2_13_20_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.88658","article-title":"Hsf1 and the Molecular Chaperone Hsp90 Support a 'rewiring Stress Response' Leading to an Adaptive Cell Size Increase in Chronic Stress","volume":"12","author":"Maiti S.","year":"2023","journal-title":"eLife"},{"issue":"14","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e34547","article-title":"Exploring the Genetic Association Between Immune Cells and Susceptibility to Osteonecrosis Using Large\u2010Scale Population Data","volume":"10","author":"Meng C.","year":"2024","journal-title":"Heliyon"},{"key":"e_1_2_13_22_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrep.2021.101090","article-title":"Regulation of Jun and Fos ap\u20101 Transcription Factors by Jnk Mapks Signaling Cascade in Areca Nut Extract Treated Kb Cells","volume":"27","author":"Nagesh R.","year":"2021","journal-title":"Biochemistry and Biophysics Reports"},{"issue":"1","key":"e_1_2_13_23_1","doi-asserted-by":"crossref","DOI":"10.3390\/dj14010018","article-title":"Unraveling Jawbone Susceptibility: Distinctive Features Underlying Medication\u2010Related Osteonecrosis","volume":"14","author":"Paczona B.","year":"2026","journal-title":"Dentistry Journal"},{"key":"e_1_2_13_24_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117623","article-title":"Understanding the Genetic Basis of Medication\u2010Related Osteonecrosis of the Jaw: A Systematic Review","volume":"201","author":"Radi S.","year":"2025","journal-title":"Bone"},{"issue":"8","key":"e_1_2_13_25_1","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1158\/1078-0432.CCR-07-1430","article-title":"Clinical, Radiographic, and Biochemical Characterization of Multiple Myeloma Patients With Osteonecrosis of the Jaw","volume":"14","author":"Raje N.","year":"2008","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_13_26_1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.csbj.2024.02.018","article-title":"Differential Gene Expression Analysis Pipelines and Bioinformatic Tools for the Identification of Specific Biomarkers: A Review","volume":"23","author":"Rosati D.","year":"2024","journal-title":"Computational and Structural Biotechnology Journal"},{"key":"e_1_2_13_27_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2024.100650","article-title":"Chinese Expert Consensus on the Diagnosis and Clinical Management of Medication\u2010Related Osteonecrosis of the Jaw","volume":"49","author":"Ruan H. J.","year":"2024","journal-title":"Journal of Bone Oncology"},{"issue":"4","key":"e_1_2_13_28_1","doi-asserted-by":"crossref","DOI":"10.3390\/dj4040032","article-title":"Prevalence of Medication\u2010Related Osteonecrosis of the Jaw in Patients With Breast Cancer, Prostate Cancer, and Multiple Myeloma","volume":"4","author":"Rugani P.","year":"2016","journal-title":"Dentistry Journal"},{"issue":"5","key":"e_1_2_13_29_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication\u2010Related Osteonecrosis of the Jaws\u20102022 Update","volume":"80","author":"Ruggiero S. L.","year":"2022","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"issue":"22","key":"e_1_2_13_30_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252212405","article-title":"Insights Into Medication\u2010Induced Osteonecrosis of the Jaw Through the Application of Salivary Proteomics and Bioinformatics","volume":"25","author":"Schwartzov\u00e1 V.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"e_1_2_13_31_1","doi-asserted-by":"crossref","DOI":"10.5037\/jomr.2023.14401","article-title":"Comparison of the Effectiveness of Conservative and Surgical Treatment of Medication\u2010Related Osteonecrosis of the Jaw: A Systematic Review","volume":"14","author":"Seluki R.","year":"2023","journal-title":"Journal of Oral and Maxillofacial Research"},{"issue":"2","key":"e_1_2_13_32_1","first-page":"126","article-title":"V\u03b39V\u03b42 T Lymphocytes Activation in Osteoporotic Patients Treated With Bisphosphonates","volume":"11","author":"Sprini D.","year":"2014","journal-title":"Clinical Cases in Mineral and Bone Metabolism"},{"issue":"6","key":"e_1_2_13_33_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101051","article-title":"The Remodelling of Actin Composition as a Hallmark of Cancer","volume":"14","author":"Suresh R.","year":"2021","journal-title":"Translational Oncology"},{"issue":"8","key":"e_1_2_13_34_1","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10785","article-title":"Pathophysiology of Medication\u2010Related Osteonecrosis of the Jaw\u2010A Minireview","volume":"7","author":"Tetradis S.","year":"2023","journal-title":"JBMR Plus"},{"issue":"8","key":"e_1_2_13_35_1","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s10096-024-04867-y","article-title":"The Importance of Antibiotic Treatment Duration in Antimicrobial Resistance","volume":"43","author":"Vitiello A.","year":"2024","journal-title":"European Journal of Clinical Microbiology & Infectious Diseases"},{"issue":"12","key":"e_1_2_13_36_1","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1039\/C9BM01181A","article-title":"Osteogenic Potential of Zn(2+)\u2010Passivated Carbon Dots for Bone Regeneration in Vivo","volume":"7","author":"Wang B.","year":"2019","journal-title":"Biomaterials Science"},{"key":"e_1_2_13_37_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1222129","article-title":"The Effect of Cytokines on Osteoblasts and Osteoclasts in Bone Remodeling in Osteoporosis: A Review","volume":"14","author":"Xu J.","year":"2023","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"e_1_2_13_38_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41368-022-00182-4","article-title":"Establishment and Assessment of Rodent Models of Medication\u2010Related Osteonecrosis of the Jaw (MRONJ)","volume":"14","author":"Yan R.","year":"2022","journal-title":"International Journal of Oral Science"},{"key":"e_1_2_13_39_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.606043","article-title":"The Role of the Immune Response in the Development of Medication\u2010Related Osteonecrosis of the Jaw","volume":"12","author":"Zhang W.","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"41","key":"e_1_2_13_40_1","doi-asserted-by":"crossref","first-page":"33996","DOI":"10.1074\/jbc.M112.369603","article-title":"The Small GTPase RhoA Regulates the Contraction of Smooth Muscle Tissues by Catalyzing the Assembly of Cytoskeletal Signaling Complexes at Membrane Adhesion Sites","volume":"287","author":"Zhang W.","year":"2012","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"e_1_2_13_41_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1615\/CritRevImmunol.2018025874","article-title":"Does Tnf Promote or Restrain Osteoclastogenesis and Inflammatory Bone Resorption?","volume":"38","author":"Zhao B.","year":"2018","journal-title":"Critical Reviews in Immunology"},{"issue":"2","key":"e_1_2_13_42_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1084\/jem.20111566","article-title":"TNF\u2010Induced Osteoclastogenesis and Inflammatory Bone Resorption Are Inhibited by Transcription Factor RBP\u2010J","volume":"209","author":"Zhao B.","year":"2012","journal-title":"Journal of Experimental Medicine"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:41:12Z","timestamp":1784518872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":41,"alternative-id":["10.1111\/odi.70438"],"URL":"https:\/\/doi.org\/10.1111\/odi.70438","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"odi.70438"}}