{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:44:12Z","timestamp":1785818652317,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prevalence, onset, and contributing factors of oral mucosal lesions associated with orthodontic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive database search (PubMed, Scopus, Web of Science, Embase, Cochrane Library, and Google Scholar) was conducted according to PRISMA. Random\u2010effects meta\u2010analyses were conducted to estimate pooled prevalence and subgroup analyses of associations, where appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 18 studies met inclusion criteria, revealing a pooled prevalence of 58% for orthodontic appliance\u2013associated oral lesions (95% CI: 50%\u201366%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200973.9%). Traumatic lesions showed significant variation by lesion type (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0093), with ulceration\/erosion being the most prevalent. Allergic stomatitis and lichenoid reactions had a prevalence of 18% (95% CI: 13%\u201325%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200978%), while gingival overgrowth was at 54% (95% CI: 34%\u201373%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200996.8%). The strongest association with oral lesions was treatment duration (pooled effect estimate\u2009=\u20094.61; 95% CI: 3.15\u20136.75), followed by lifestyle and appliance\u2010related factors. Findings should be interpreted cautiously.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral mucosal lesions are commonly reported among patients undergoing orthodontic treatment, with considerable variability in lesion type, timing, and associated risk factors. These findings highlight the importance of preventive strategies, regular monitoring, and individualized patient management during orthodontic care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review and Meta\u2010 Analysis Protocol Registration<\/jats:title>\n                    <jats:p>PROSPERO\u2014CRD: 420251078164<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70441","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:53:28Z","timestamp":1785815608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orthodontic Appliance Associated Oral Lesions: A Systematic Review and Meta\u2010Analysis of Clinical Prevalence, Onset, and Contributing Factors"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5473-9808","authenticated-orcid":false,"given":"Sally Abd El\u2010Meniem","family":"El\u2010Haddad","sequence":"first","affiliation":[{"name":"Preventive Dental Sciences Department, College of Dentistry Dar AlUloom University, Alfalah  Riyadh Saudi\u00a0Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-8482","authenticated-orcid":false,"given":"Ferdous","family":"Bukhary","sequence":"additional","affiliation":[{"name":"Preventive Dental Sciences Department, College of Dentistry Dar AlUloom University, Alfalah  Riyadh Saudi\u00a0Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0091-2106","authenticated-orcid":false,"given":"Yara F.","family":"AlMuaigl","sequence":"additional","affiliation":[{"name":"Shoaa Medical Complex  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamya Abdulmonem","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Private Sector  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan Hussain","family":"Alawad","sequence":"additional","affiliation":[{"name":"Private Sector  Dhahran Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtesam Abdullah","family":"Al\u2010Alawi","sequence":"additional","affiliation":[{"name":"Private Sector  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Abdelraouf","family":"Elati","sequence":"additional","affiliation":[{"name":"Ram Clinics  Dhahran Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maei H.","family":"Almoallim","sequence":"additional","affiliation":[{"name":"College of Dentistry Dar AlUloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah M.","family":"Towaireet","sequence":"additional","affiliation":[{"name":"College of Dentistry Dar AlUloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwaq S.","family":"Alosaimi","sequence":"additional","affiliation":[{"name":"College of Dentistry Dar AlUloom University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad M.","family":"ElShall","sequence":"additional","affiliation":[{"name":"Gharbia Directorate of Health Affairs, Ministry of Health  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","article-title":"Oral Mucosal Lesions Associated With Fixed Orthodontic Appliances","volume":"13","author":"Abd Ali M. 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