{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:08:27Z","timestamp":1788851307674,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate salivary apelin levels in individuals with and without type 1 diabetes presenting an intact periodontium and varying degrees of plaque\u2010induced gingival inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Saliva samples were collected; and whole\u2010mouth clinical periodontal measurements were recorded in type 1 diabetes and systemically healthy participants. Salivary apelin concentrations were determined using ELISA. Data were analysed statistically using the Shapiro\u2013Wilk test for normality of distribution, the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test for intergroup differences, and Spearman's rank correlation analysis to assess correlations between clinical and biochemical parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 99 participants; including 59 individuals in the type 1 diabetes group and 40 in the systemically healthy were included. The two groups were similar in terms of age, gender distribution, and smoking status (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The salivary apelin concentration in the diabetic group (4647.13\u2009\u00b1\u20098584.45\u2009pg\/mL) was almost twice that in the systemically healthy group (2704.12\u2009\u00b1\u20093006.73\u2009pg\/mL) without statistically significant difference (0.114). Clinical periodontal measurements were similar between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Neither gender nor smoking status had a significant effect on apelin levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limitations of this study, the observed trend toward higher salivary apelin levels in patients with type 1 diabetes may suggest a possible association that requires confirmation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70467","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:38:55Z","timestamp":1787287135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Apelin Levels and Periodontal Findings in Individuals With\/Without Type 1 Diabetes and Varying Degrees of Gingival Inflammation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2447-5371","authenticated-orcid":false,"given":"Demet Efe","family":"Yava\u015fo\u011flu","sequence":"first","affiliation":[{"name":"Department of Periodontology Ege University, School of Dentistry  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-5947","authenticated-orcid":false,"given":"Andressa V. B.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Operative Dentistry University Medical Centre of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3082-5970","authenticated-orcid":false,"given":"Mehmet","family":"Demirba\u015f","sequence":"additional","affiliation":[{"name":"Department of Periodontology Ege University, School of Dentistry  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics Ege University, School of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahat","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Plastic Surgery University Medical Centre of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-1885","authenticated-orcid":false,"given":"James","family":"Deschner","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Operative Dentistry University Medical Centre of the Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-5801","authenticated-orcid":false,"given":"Nurcan","family":"Buduneli","sequence":"additional","affiliation":[{"name":"Department of Periodontology Ege University, School of Dentistry  \u0130zmir T\u00fcrkiye"},{"name":"Department of Periodontology Saveetha Dental College &amp; 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N.AVB P.Meri\u00e7 Kantar P.Cores Ziskoven J.Deschner andN.Buduneli.2023. \u201cGingival Crevicular Fluid Levels of Apelin Correlates With Clinical Periodontal Diagnosis.\u201d28:50.https:\/\/doi.org\/10.1007\/s00784\u2010023\u201005461\u2010w.","DOI":"10.1007\/s00784-023-05461-w"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:32:13Z","timestamp":1788849133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":44,"alternative-id":["10.1111\/odi.70467"],"URL":"https:\/\/doi.org\/10.1111\/odi.70467","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"assertion":[{"value":"2026-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"odi.70467"}}