{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:10:09Z","timestamp":1788930609228,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma is the most prevalent malignant neoplasm in the head and neck region, and its prognosis is influenced by various histopathological and clinical factors. pTNM tumor staging and invasion patterns are fundamental for predicting therapeutic response and patient survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study analyzing 283 cases of oral squamous cell carcinoma treated at Haroldo Jua\u00e7aba Hospital. Histopathological and clinical information was collected, including tumor grade, pTNM, invasion pattern, and response to therapy. Statistical analyses were carried out in SPSS software using Fisher's tests, Pearson's chi\u2010squared, log\u2010rank Mantel\u2013Cox, and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The presence of pN2\/pN3 nodal metastases, compromised margins, and a history of smoking were associated with a worse prognosis. Adjuvant radiotherapy alone showed longer disease\u2010free survival. Perineural invasion and a low stromal infiltrating lymphocyte score were significant negative prognostic factors. Multivariate analysis showed that patients with lymph node involvement (HR\u2009=\u20091.84; 95% CI: 1.02\u20133.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) and stromal infiltrating lymphocytes (HR\u2009=\u20090.44; 95% CI: 0.21\u20130.089;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) had an increased risk of recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lymph node involvement and low lymphocyte infiltration are determining factors for tumor recurrence, as are the presence of comorbidities, alcohol, and smoking, reinforcing the need for continuous monitoring and personalized therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70473","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:54:49Z","timestamp":1788929689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Histopathologic Parameters and Patterns of Invasion in Oral Squamous Cell Carcinoma and Their Correlation With Patient Survival"],"prefix":"10.1111","author":[{"given":"Ana Mirian da Silva","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janderson Fernando","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-3587","authenticated-orcid":false,"given":"Tayane Oliveira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-9475","authenticated-orcid":false,"given":"Fabr\u00edcio Bitu","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6155-9882","authenticated-orcid":false,"given":"Erick Ibraim Carlos","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-6877","authenticated-orcid":false,"given":"Ana Paula Negreiros Nunes","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Viana","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Dentistry Haroldo Jua\u00e7aba Hospital\/Ceara Cancer Institute  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-5627","authenticated-orcid":false,"given":"Dayrine Silveira","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-9027","authenticated-orcid":false,"given":"Paulo Goberl\u00e2nio","family":"de Barros Silva","sequence":"additional","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-3315","authenticated-orcid":false,"given":"Thinali Sousa","family":"Dantas","sequence":"additional","affiliation":[{"name":"Department of Dentistry Christus University Center  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00428-020-02930-5","article-title":"Stromal Categorization in Early Oral Tongue Cancer","volume":"478","author":"Almangush A.","year":"2021","journal-title":"Virchows Archiv"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.25114"},{"key":"e_1_2_9_4_1","unstructured":"College of American Pathologists.2026.\u201cHead and Neck Biomarker Reporting Template.\u201dVersion 2.3.0.0 [Internet]. College of American Pathologists; 2026 [cited 2026 Aug 21].https:\/\/www.cap.org\/wp\u2010content\/uploads\/protocols\/HN.Bmk_2.3.0.0.REL_CAPCP.pdf."},{"issue":"10","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15102688","article-title":"OSCC in Never\u2010Smokers and Never\u2010Drinkers Is Associated With Increased Expression of Tumor\u2010Infiltrating Lymphocytes and Better Survival","volume":"15","author":"Fiedler M.","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"2","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5935\/1808-8694.20130041","article-title":"Head and Neck Cancer: Causes, Prevention, and Treatment","volume":"79","author":"Galbiatti A. L. S.","year":"2013","journal-title":"Brazilian Journal of Otorhinolaryngology"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijom.2017.07.019","article-title":"Marginal or Segmental Mandibulectomy: Treatment Modality Selection for Oral Cancer: A Systematic Review and Meta\u2010Analysis","volume":"47","author":"Gou L.","year":"2018","journal-title":"International Journal of Oral and Maxillofacial Surgery"},{"issue":"9","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.joms.2019.03.007","article-title":"Are Comorbidities Associated With Overall Survival in Patients With Oral Squamous Cell Carcinoma?","volume":"77","author":"Jariod\u2010Ferrer U. M.","year":"2019","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"key":"e_1_2_9_9_1","unstructured":"Jos\u00e9 Alencar Gomes da Silva National Cancer Institute (INCA).2022.\u201cEarly Diagnosis of Oral Cancer [Internet].\u201d Rio de Janeiro: INCA.https:\/\/www.inca.gov.br\/sites\/ufu.sti.inca.local\/files\/media\/document\/livro\u2010diagnostico\u2010precoce\u2010cancer\u2010boca\u20102022.pdf."},{"issue":"1","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40902-024-00410-3","article-title":"Prognostic Factors of Oral Squamous Cell Carcinoma: The Importance of Recurrence and pTNM Stage","volume":"46","author":"Kim M. J.","year":"2024","journal-title":"Maxillofacial Plastic and Reconstructive Surgery"},{"issue":"1","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/lio2.4","article-title":"Perineural Invasion in Squamous Cell Carcinoma of the Oral Cavity: Histology, Tumor Stage, and Outcome","volume":"1","author":"Laske R. D.","year":"2016","journal-title":"Laryngoscope Investigative Otolaryngology"},{"issue":"5","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41571-022-00603-7","article-title":"HPV\u2010Associated Oropharyngeal Cancer: Epidemiology, Molecular Biology, and Clinical Management","volume":"19","author":"Lechner M.","year":"2022","journal-title":"Nature Reviews. Clinical Oncology"},{"issue":"6","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/jso.25386","article-title":"Number of Positive Lymph Nodes Better Predicts Survival for Oral Cavity Cancer","volume":"119","author":"Lee H.","year":"2019","journal-title":"Journal of Surgical Oncology"},{"issue":"1","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/hed.26487","article-title":"Impact of Age and Comorbidity on Survival Among Patients With Oral Cavity Squamous Cell Carcinoma","volume":"43","author":"Patel K. B.","year":"2021","journal-title":"Head & Neck"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.2147\/CMAR.S201568","article-title":"Clinical Relevance and Significance of Programmed Death\u2010Ligand 1 Expression, Tumor\u2010Infiltrating Lymphocytes, and p16 Status in Sinonasal Squamous Cell Carcinoma","volume":"11","author":"Quan H.","year":"2019","journal-title":"Cancer Management and Research"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.941351","article-title":"Prognostic Implications of Preoperative Systemic Inflammatory Markers in Oral Squamous Cell Carcinoma, and Correlations With the Local Immune Tumor Microenvironment","volume":"13","author":"Ruiz\u2010Ranz M.","year":"2022","journal-title":"Frontiers in Immunology"},{"issue":"3","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.4317\/jced.57477","article-title":"Prognostic Factors on Surgically and Non\u2010Surgically Treated Oral Squamous Cell Carcinoma: Advances in Survival in Fifteen Years of Follow Up","volume":"13","author":"Silva P. B.","year":"2021","journal-title":"Journal of Clinical and Experimental Dentistry"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/diagnostics12051062","article-title":"Prognostic Value of Perineural Invasion on Survival and Recurrence in Oral Squamous Cell Carcinoma","volume":"12","author":"Spoerl S.","year":"2022","journal-title":"Diagnostics"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-021-07958-7","article-title":"Central Neck Lymph Node Metastasis in Oral Squamous Cell Carcinoma at the Floor of the Mouth","volume":"21","author":"Zhang S.","year":"2021","journal-title":"BMC Cancer"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/odi.70473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.70473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:54:52Z","timestamp":1788929692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.70473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":18,"alternative-id":["10.1111\/odi.70473"],"URL":"https:\/\/doi.org\/10.1111\/odi.70473","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"odi.70473"}}