{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:24:10Z","timestamp":1787289850675,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To evaluate the association between oral mucosal diseases, oral health\u2010related quality of life (OHRQoL), and depressive symptoms, and to explore differences across categories.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n In this cross\u2010sectional observational pilot study, consecutive outpatients with oral mucosal disease were enrolled at the Dental Clinic of the Policlinico of Bari over one year. OHRQoL and depressive symptoms were assessed using the Oral Health Impact Profile\u201014 (OHIP\u201014) and Patient Health Questionnaire\u20109 (PHQ\u20109). Participants were classified into four diagnostic groups: idiopathic\/chronic orofacial pain syndromes, autoimmune diseases, oral potentially malignant disorders (OPMDs), and reactive\u2010inflammatory\/traumatic lesions. Nonparametric tests and a multivariable negative binomial regression model were applied.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty\u2010six patients were included, and OHIP\u201014 and PHQ\u20109 scores showed a moderate positive correlation (Spearman's\n p<\/jats:italic>\n \u2009=\u20090.41;\n p<\/jats:italic>\n \u2009<\u20090.01). Kruskal\u2013Wallis testing suggested a difference in OHIP\u201014 scores across groups (\n p<\/jats:italic>\n \u2009=\u20090.03), with the greatest exploratory post hoc difference between chronic orofacial pain syndromes and OPMDs (adjusted\n p<\/jats:italic>\n \u2009=\u20090.03), whereas PHQ\u20109 scores did not differ across groups (\n p<\/jats:italic>\n \u2009=\u20090.93).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Diagnostic category appeared to influence OHRQoL, but not depressive symptoms; however, findings should be considered exploratory.<\/jats:p>\n <\/jats:sec>\n \n Clinical Significance<\/jats:title>\n These exploratory findings suggest that OHRQoL assessment may complement oral mucosal disease evaluation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.70475","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:35:36Z","timestamp":1787286936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Health\u2013Related Quality of Life and Depressive Symptoms in Oral Mucosal Diseases: A Cross\u2010Sectional Observational Pilot Study"],"prefix":"10.1111","author":[{"given":"Domenico","family":"Cutecchia","sequence":"first","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Marvulli","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE\u2010J) University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9880-0481","authenticated-orcid":false,"given":"Vittorio","family":"Dibello","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Dysfunction Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Odontostomatological Specialties University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-3739","authenticated-orcid":false,"given":"Massimo","family":"Petruzzi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-0800","authenticated-orcid":false,"given":"Domenico","family":"De Falco","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/jcpe.14074","article-title":"Periodontitis and Oral Health\u2013Related Quality of Life: A Systematic Review and Meta\u2010Analysis","volume":"52","author":"Agnese C. 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