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Clinical parameters [periodontal inflamed surface area (PISA), Plaque Index (PLI), Gingival Index (GI)], mouthrinse aMMP\u20108, serum hsCRP, and HbA1c were measured at baseline and 3\u2009months posttreatment. Analyses included paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, Pearson correlation, and linear mixed effect models (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diabetes and prediabetes patients showed improvements in PISA, PLI, GI, aMMP\u20108, HbA1c (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and hsCRP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) 3\u2009months post\u2010NSPT. Diabetes patients maintained improvements, but hsCRP and HbA1c were insignificant in prediabetes. Diabetes participants had greater HbA1c reduction (\u22120.78%), while prediabetes participants had larger aMMP\u20108 decrease (\u221220.91\u2009ng\/mL). Obesity reduced aMMP\u20108 and PLI responses, with no sex effect. Several variables showed significant correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NSPT reduces systemic inflammation and improves glycemic control, particularly in diabetes. HbA1c responds best in diabetes, aMMP\u20108 in prediabetes. Mouthrinse aMMP\u20108 PoC test enables real\u2010time periodontal monitoring and supports diabetes risk screening in dental and medical care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The registration number: PACTR202608587329540; Trial registry: Pan African Clinical Trials Registry (PACTR)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70481","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:52:26Z","timestamp":1789530746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontal Therapy\u2013Related Changes in Clinical Parameters, Active\u2010Matrix Metalloproteinase\u20108 and C\u2010Reactive Protein in Prediabetes and 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