{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:02:45Z","timestamp":1789977765731,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We hypothesized that periodontal tissue disruption and vascular dysfunction may coexist in adolescence, indicating that early manifestations of vascular risk may already be detectable at this stage of the life course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A population\u2010based sample of 2515 adolescents aged 18\u201319\u2009years was obtained from the RPS Cohort and additional sources. We examined the relationships between\n                      <jats:italic>Periodontitis<\/jats:italic>\n                      (a latent variable representing the shared variance of bleeding on probing, probing depth \u2265\u20094\u2009mm, and clinical attachment loss \u2265\u20093\u2009mm) and the\n                      <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                      (a latent variable formed by carotid\u2010femoral pulse wave velocity, systolic and diastolic blood pressure). Socioeconomic status, smoking, alcohol, and obesity were adjusted in structural equation models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Periodontitis<\/jats:italic>\n                      and\n                      <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                      were correlated [Standardized Coefficient (SC): 0.100;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004]. A higher socioeconomic status was negatively associated with both\n                      <jats:italic>Periodontitis<\/jats:italic>\n                      (SC: \u22120.112;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and\n                      <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                      (SC: \u22120.061;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). The strongest association was observed between obesity and the\n                      <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                      (SC: 0.393;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), followed by its association with\n                      <jats:italic>Periodontitis<\/jats:italic>\n                      (SC: 0.114;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Periodontal and vascular alterations appear to co\u2010occur and may represent early manifestations of cardiovascular risk influenced by shared socioeconomic and metabolic determinants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70492","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:09:26Z","timestamp":1789974566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis Is Associated With Higher Blood Pressure and Pulse Wave Velocity in Late Adolescence: A Population\u2010Based Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-7930","authenticated-orcid":false,"given":"Susilena Arouche","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-6300","authenticated-orcid":false,"given":"Gustavo G.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-9700","authenticated-orcid":false,"given":"Cayara Mattos","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Maria Coelho","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"},{"name":"Department of Public Health Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rika B\u00e1rbara Abreu Fonseca","family":"Thomaz","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"},{"name":"Department of Public Health Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-7618","authenticated-orcid":false,"given":"Cecilia Claudia Costa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"},{"name":"Department of Public Health Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14218"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12933\u2010022\u201001724\u20100\/TABLES\/3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1992.tb01743.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.1.50"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.03.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517745326"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1034\/j.1600-0714.2000.291004.x","article-title":"Vascular Remodelling in Chronic Inflammatory Periodontal Disease","volume":"29","author":"Chapple C. 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