{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:53:21Z","timestamp":1789466001157,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontitis prevalence increases with age, yet \u201celderly periodontitis\u201d is not merely cumulative plaque exposure. Aging remodels mucosal immunity, elevates chronic inflammation, and promotes senescent cell accumulation with pro\u2010inflammatory secretory phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To critically evaluate the self\u2010reinforcing oral microbiome\u2013inflammaging axis in elderly periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative synthesis of mechanistic studies, human cohorts, and preclinical models investigating interactions between oral microbial ecology, immunosenescence, cellular senescence, and inflammaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dysbiotic biofilms deliver persistent pressure interpreted by aged immune\u2013stromal networks with heightened inflammatory gain. Mechanistic studies implicate aging\u2010sensitive TLR9 sensing, age\u2010amplified inflammasome\u2010linked macrophage responses to\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P. gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      , and senescent niches that potentiate inflammation. Microbes directly induce senescence programs, including epithelial senescence and exosome\u2010mediated paracrine immune senescence. Systemically, periodontitis induces multi\u2010organ frailty\u2010like phenotypes, neuroinflammatory changes, persistent gut dysbiosis, and altered metabolomes despite local therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elderly periodontitis represents a geroscience\u2010relevant disorder where dysbiosis and biological aging jointly establish a self\u2010sustaining inflammatory ecosystem. Priority gaps include longitudinal elderly cohorts integrating microbiome function with senescence markers and stratified trials combining biofilm control with host modulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70493","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:08:57Z","timestamp":1789456137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Oral Microbiome\u2013Inflammaging Axis in Elderly Periodontitis: Emerging Immunopathogenic and Systemic Mechanisms"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8802-1158","authenticated-orcid":false,"given":"Jabborova","family":"Feruza","sequence":"first","affiliation":[{"name":"Department of Therapeutic Dentistry Bukhara State Medical Institute Named after Abu Ali ibn Sino  Bukhara Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5054-9365","authenticated-orcid":false,"given":"Masharipov","family":"Otajon","sequence":"additional","affiliation":[{"name":"Department of Therapeutic and Orthopedic Dentistry Urgench State Medical Institute  Urgench Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6903-3888","authenticated-orcid":false,"given":"Mukimov","family":"Shaxobiddin","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry Bukhara State Medical Institute Named after Abu Ali ibn Sino  Bukhara Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afakova","family":"Mamura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Therapeutic Dentistry Tashkent State Medical University  Tashkent 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