{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:57:39Z","timestamp":1790654259298,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the association between Cathepsin K (CatK) levels in gingival crevicular fluid (GCF) and saliva with periodontal health and disease, and to evaluate the effects of non\u2010surgical periodontal therapy (NSPT) on these biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      GCF and saliva samples were collected from periodontally healthy individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933) and patients diagnosed with periodontitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933). The periodontitis group underwent NSPT, and follow\u2010up samples were collected from the same individuals one month after treatment. CatK concentrations in both GCF and saliva were measured using ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, CatK levels in both GCF and saliva were significantly higher in periodontitis patients than in periodontally healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). NSPT resulted in significant reductions in CatK levels in both GCF and saliva (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Salivary CatK decreased to values comparable to healthy subjects, whereas GCF CatK, although reduced, remained higher than healthy levels. A strong positive correlation between salivary and GCF CatK observed before treatment (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) disappeared after NSPT. Multiple regression identified cohort and gingival index as the strongest independent predictors of CatK concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CatK levels in both GCF and saliva were associated with periodontal status and responded significantly to NSPT. These findings suggest that CatK may have potential as an adjunctive biomarker for monitoring short\u2010term biochemical changes following NSPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70509","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:34:11Z","timestamp":1790652851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Nonsurgical Periodontal Therapy on Cathepsin\u2010K in Saliva and Gingival Crevicular Fluid"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-9461","authenticated-orcid":false,"given":"Ali Batuhan","family":"Bay\u0131rl\u0131","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry Mugla S\u0131tk\u0131 Kocman University  Mugla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-5978","authenticated-orcid":false,"given":"Ayla","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-6740","authenticated-orcid":false,"given":"Mehmetcan","family":"Uytun","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Mugla S\u0131tk\u0131 Kocman University  Mugla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-1442","authenticated-orcid":false,"given":"Ercan","family":"Saruhan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine Mugla S\u0131tk\u0131 Kocman University  Mugla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144256"},{"issue":"4","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.21448\/ijsm.1470256","article-title":"Comparison of Matrix Metalloproteinase Levels in Periodontal Pockets Treated With Chlorhexidine and Propolis","volume":"11","author":"Bay\u0131rl\u0131 A. 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