{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:57:55Z","timestamp":1790654275260,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["81991500"],"award-info":[{"award-number":["81991500"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["81991502"],"award-info":[{"award-number":["81991502"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506303"],"award-info":[{"award-number":["2023YFC2506303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1108900"],"award-info":[{"award-number":["2024YFA1108900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2402901"],"award-info":[{"award-number":["2022YFC2402901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sleep regulates immune and inflammatory processes and may influence periodontal health, though evidence remains inconsistent. This meta\u2010analysis evaluated the association between sleep characteristics, including sleep quality and sleep duration, and periodontal disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic searches up tos May 2025 identified eligible studies. Sleep\u2010related exposures were assessed using validated questionnaires or sleep duration (&lt;\u20097\u2009h); periodontal outcomes were defined by clinical examination or self\u2010report. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model, depending on heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009126,425) met inclusion criteria, of which nine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955,524) provided adjusted odds ratios for meta\u2010analysis. Six assessed questionnaire\u2010based sleep quality and three assessed sleep duration alone. Across these heterogeneous exposure definitions, adverse sleep characteristics were associated with greater odds of PD (OR\u2009=\u20091.25; 95% CI: 1.11\u20131.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200953.8%). Sensitivity analyses showed no substantial change in the pooled estimate, and no statistically significant evidence of publication bias was detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adverse sleep characteristics were associated with greater odds of PD, with a stronger association observed for severe periodontitis in subgroup analysis. However, the certainty of evidence was very low, and prospective studies are warranted to clarify causality<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70511","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:33:49Z","timestamp":1790652829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep Quality and Risk of Periodontal Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5772-2527","authenticated-orcid":false,"given":"Binbin","family":"Nan","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-1099","authenticated-orcid":false,"given":"Jing","family":"Kang","sequence":"additional","affiliation":[{"name":"Centre of Clinical Translational Sciences, Faculty of Dentistry, Oral, and Craniofacial Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2565-0341","authenticated-orcid":false,"given":"Honghui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry Zhejiang Mental Health Center, Tongde Hospital of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-8660","authenticated-orcid":false,"given":"Xiaojun","family":"Li","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-4432","authenticated-orcid":false,"given":"Qianming","family":"Chen","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9184-3462","authenticated-orcid":false,"given":"Zijian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou 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