{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:59:39Z","timestamp":1790834379839,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2025\/15106\u20106"],"award-info":[{"award-number":["2025\/15106\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Proliferative verrucous leukoplakia is an oral potentially malignant disorder with a difficult diagnosis. A band\u2010like chronic inflammatory infiltrate is frequently described in early lesions, but its prevalence and prognostic relevance remain unclear. This study aimed to estimate the prevalence of this feature in proliferative verrucous leukoplakia and assess its prognostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were conducted according to PRISMA guidelines, with protocol registration in PROSPERO (CRD420251249570). Electronic databases and gray literature were searched. Observational studies reporting a band\u2010like chronic inflammatory infiltrate in lesions from patients with proliferative verrucous leukoplakia were included. Data extraction and risk of bias assessment were performed independently. Random effects models estimated pooled prevalence and odds ratios for malignant transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven studies including 307 patients were analyzed. The pooled prevalence of a band\u2010like chronic inflammatory infiltrate was 57%. Malignant transformation occurred in 39.5% of cases with this feature and 53% of cases without it. Meta\u2010analysis revealed no statistically significant association between a band\u2010like chronic inflammatory infiltrate and malignant transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Band\u2010like chronic inflammatory infiltrates are common in proliferative verrucous leukoplakia, but current evidence is insufficient to determine whether this feature is associated with malignant transformation and clinically meaningful effects cannot be excluded.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70514","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:12:23Z","timestamp":1790831543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Band\u2010Like Chronic Inflammatory Infiltrate in Proliferative Verrucous Leukoplakia: A Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3740-5127","authenticated-orcid":false,"given":"Daniel Lobato Ferreira","family":"Ferraz","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-0283","authenticated-orcid":false,"given":"Brenda Corr\u00eaa","family":"Santos","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3998-4268","authenticated-orcid":false,"given":"Ana Carolina Evangelista","family":"Colaf\u00eamina","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3828-0107","authenticated-orcid":false,"given":"Ivan Jos\u00e9","family":"Correia\u2010Neto","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-0065","authenticated-orcid":false,"given":"Marcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815586779"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2023.152104"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010021\u201001333\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010022\u201001021\u2010x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2022.01.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13317"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES\u201022\u201000430"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.18912"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e839"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010019\u201001006\u20104"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13246"},{"issue":"2","key":"e_1_2_12_13_1","first-page":"e142","article-title":"Letter to the Editor: Development of Proliferative Verrucous Leukoplakia (PVL) in Oral Lichen Planus: Is It Not a Clinical Spectrum of PVL?","volume":"22","author":"Fernandes D. 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