{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:54:42Z","timestamp":1790747682979,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401186"],"award-info":[{"award-number":["82401186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401138"],"award-info":[{"award-number":["82401138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Periodontitis treatment centers on three pillars: antibacterial, anti\u2010inflammatory, and regenerative approaches. This review aims to demonstrate that resveratrol (RSV) simultaneously targets all three core components, positioning it as a multifunctional disease\u2010modifying agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a narrative review of RSV in periodontitis by searching PubMed and Web of Science from inception to July 2026. Rather than focusing solely on its well\u2010established antioxidant properties, we comprehensively investigated its multifaceted mechanisms across the three key pathological dimensions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RSV demonstrates broad\u2010spectrum antibacterial activity by inhibiting biofilm formation, suppressing bacterial ATP synthase, inducing DNA damage, and disrupting efflux pumps to counteract antibiotic resistance. RSV modulates host immune responses through multiple signaling pathways, primarily via SIRT1\u2010mediated epigenetic regulation. RSV also interacts with immune cells and regulates innate immune memory, thereby reducing the risk of disease recurrence associated with trained immunity\u2010induced hyperinflammation. Furthermore, RSV orchestrates stem cell recruitment via SDF\u20101\u03b1 signaling and cytoskeletal reorganization, while directing cell differentiation through mitochondrial quality control and epigenetic modifications, thereby promoting endogenous periodontal regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review provides a comprehensive analysis of the multifaceted roles of RSV in antibacterial action, immunomodulation, and tissue regeneration, highlighting its potential as a multifunctional agent against the complex pathological progression of periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70516","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:56:06Z","timestamp":1790744166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Antioxidant: The Multifaceted Role of Resveratrol as an Antibacterial, Immunomodulatory, and Pro\u2010Regenerative Agent in Periodontitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5553-0282","authenticated-orcid":false,"given":"Yu\u2010Jie","family":"Tan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology School of Stomatology, the Fourth Military Medical University  Xi'an Shaanxi 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