{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:59:20Z","timestamp":1790834360199,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the psychometric performance of the Hamilton Anxiety Rating Scale (HAM\u2010A) and Hamilton Depression Rating Scale (HAM\u2010D) in patients with oral lichen planus (OLP) according to clinical phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter SIPMO case\u2013control study included 395 participants: 132 patients with keratotic OLP (K\u2010OLP), 131 with non\u2010keratotic OLP (NK\u2010OLP), and 132 healthy controls (HCs). Internal consistency was assessed with Cronbach's alpha and item discrimination with item\u2013total correlations. HAM\u2010A and HAM\u2010D scores were compared between OLP patients and HCs; phenotype\u2010specific hierarchical regressions identified variables associated with anxiety and depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HAM\u2010A and HAM\u2010D showed satisfactory internal consistency in K\u2010OLP and NK\u2010OLP patients (HAM\u2010A\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.877 and 0.858; HAM\u2010D\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.768 and 0.766, respectively). Patients with OLP had significantly higher HAM\u2010A and HAM\u2010D scores than age\u2010 and sex\u2010matched controls without oral mucosal disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002, respectively). The strongest item\u2013total correlations involved depressed mood, tension, insomnia, and somatic symptoms. Poor sleep quality was independently associated with psychological burden, and pain intensity independently predicted anxiety severity in NK\u2010OLP patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HAM\u2010A and HAM\u2010D showed satisfactory psychometric performance in OLP and may support psychological assessment. Somatic and sleep\u2010related symptoms were closely associated with psychological distress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70518","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:24:35Z","timestamp":1790832275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of the Hamilton Anxiety and Depression Rating Scales in Oral Lichen Planus: A Multicenter Study by the Italian Society of Oral Pathology and Medicine"],"prefix":"10.1111","author":[{"given":"Daniela","family":"Adamo","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry University of Naples Federico II  Naples Italy"},{"name":"Department of Life Science, Health, and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3576-4670","authenticated-orcid":false,"given":"Gennaro","family":"Musella","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-6690","authenticated-orcid":false,"given":"Federica","family":"Canfora","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Calabria","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5303-0855","authenticated-orcid":false,"given":"Simone","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-9734","authenticated-orcid":false,"given":"Carlo","family":"Lajolo","sequence":"additional","affiliation":[{"name":"Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, School of Dentistry Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-2029","authenticated-orcid":false,"given":"Gioele","family":"Gioco","sequence":"additional","affiliation":[{"name":"Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, School of Dentistry Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3427-0514","authenticated-orcid":false,"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-9439","authenticated-orcid":false,"given":"Katia","family":"Rupel","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Biasotto","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-2239","authenticated-orcid":false,"given":"Margherita","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Unit of Oral and Maxillofacial Surgery Ca' Foncello Hospital  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-806X","authenticated-orcid":false,"given":"Maddalena","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Oral Medicine and Laser Surgery Unit, University Center of Dentistry University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-3716","authenticated-orcid":false,"given":"Paolo","family":"Vescovi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Oral Medicine and Laser Surgery Unit, University Center of Dentistry University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-6979","authenticated-orcid":false,"given":"Amerigo","family":"Giudice","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0543-2557","authenticated-orcid":false,"given":"Cristina","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-7834","authenticated-orcid":false,"given":"Paolo","family":"Arduino","sequence":"additional","affiliation":[{"name":"Oral Medicine Section, Department of Surgical Science, CIR Dental School University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-0799","authenticated-orcid":false,"given":"Alessio","family":"Gambino","sequence":"additional","affiliation":[{"name":"Oral Medicine Section, Department of Surgical Science, CIR Dental School University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-1203","authenticated-orcid":false,"given":"Monica","family":"Pentenero","sequence":"additional","affiliation":[{"name":"Department of Oncology, Oral Medicine and Oral Oncology Unit University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5166-9492","authenticated-orcid":false,"given":"Olga Anna","family":"Furch\u00ec","sequence":"additional","affiliation":[{"name":"Department of Oncology, Oral Medicine and Oral Oncology Unit University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0195-7694","authenticated-orcid":false,"given":"Davide Bartolomeo","family":"Gissi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Section of Oral Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-8615","authenticated-orcid":false,"given":"Andrea","family":"Gabusi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, Section of Oral Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Azzi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Technological Innovation University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Insubria  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9963-8052","authenticated-orcid":false,"given":"Gianluca","family":"Tenore","sequence":"additional","affiliation":[{"name":"Department of Oral Sciences and Maxillofacial Surgery University of Rome La Sapienza  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-3354","authenticated-orcid":false,"given":"Andrea","family":"Santarelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Dental Sciences Marche Polytechnic University  Ancona 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University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-4893","authenticated-orcid":false,"given":"Lorenzo","family":"Lo Muzio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-9411","authenticated-orcid":false,"given":"Massimo","family":"Aria","sequence":"additional","affiliation":[{"name":"Department of Economics and Statistics University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-9212","authenticated-orcid":false,"given":"Luca","family":"D'Aniello","sequence":"additional","affiliation":[{"name":"Department of Economics and Statistics University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Davide","family":"Mignogna","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Oral Sciences and Maxillofacial Surgery University of Rome La Sapienza  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SIPMO (Italian Society of Oral Pathology and Medicine)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-022-02181-7","article-title":"Where Do You Live? 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