{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:53:47Z","timestamp":1791269627853,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment\u2010related, and survival features of OSJ in Latin America.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan\u2013Meier analysis and Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 119 OSJ cases were included. The median age was 33\u2009years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) and multimodal or nonsurgical management (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12\u2009months and 37.5% at 60\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70519","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:40:13Z","timestamp":1791268813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-3950","authenticated-orcid":false,"given":"Victor Zanetti","family":"Drumond","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Pathology and Clinical Dentistry School of Dentistry, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-3950","authenticated-orcid":false,"given":"Jos\u00e9 Alcides Almeida","family":"de Arruda","sequence":"additional","affiliation":[{"name":"School of Dentistry Universidade Federal de Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0596-1527","authenticated-orcid":false,"given":"Mariana","family":"Villaroel\u2010Dorrego","sequence":"additional","affiliation":[{"name":"School of Dentistry Universidad Central de Venezuela  Caracas Venezuela"},{"name":"School of Dentistry Universidad Santa Mar\u00eda  Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-1565","authenticated-orcid":false,"given":"Leonardo Amaral","family":"Dos Reis","sequence":"additional","affiliation":[{"name":"School of Dentistry Universidade Federal de Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-471X","authenticated-orcid":false,"given":"Gerhilde Callou","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Pathology School of Dentistry, Universidade de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-936X","authenticated-orcid":false,"given":"Lauren Frenzel","family":"Schuch","sequence":"additional","affiliation":[{"name":"Department of Diagnosis in Pathology and Oral Medicine School of Dentistry, Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6147-7658","authenticated-orcid":false,"given":"Carolina Louzada","family":"Menna\u2010Barreto","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry, Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-5965","authenticated-orcid":false,"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry, Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8968-2243","authenticated-orcid":false,"given":"Paula Celeghini","family":"Goulart","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Pathology and Clinical Dentistry School of Dentistry, Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-9429","authenticated-orcid":false,"given":"Guilherme 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