{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:56:53Z","timestamp":1790744213822,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004006","name":"Bilimsel Ara\u015ftirma Projeleri Birimi, Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["599\/15122006"],"award-info":[{"award-number":["599\/15122006"]}],"id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to evaluate the impact of non\u2010surgical periodontal treatment (NSPT) on systemic inflammatory phenotype and lipid profiles in young adults with severe (Stage III\u2013IV\/Grade C) periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty systemically healthy patients with severe periodontitis and 20 healthy controls were recruited in this prospective, parallel\u2010group controlled study. Periodontal parameters and systemic biomarkers, including inflammatory, endothelial, and lipid biomarkers, were evaluated at baseline and re\u2010measured at 2 and 6\u2009months post\u2010NSPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant reductions in periodontal parameters were observed after 2\u2009months and remained stable over 6\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while bleeding, probing pocket depth, and clinical attachment levels remained significantly higher in the periodontitis patients compared to the healthy group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Circulating hs\u2010CRP, triglycerides, vWf, IL\u20106, IL\u20101ra, tPA, sTNFRII, and albumin were significantly higher while HDL cholesterol was significantly lower in periodontitis patients at baseline compared to the healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). hs\u2010CRP, IL\u20106, IL\u20101ra, sTNFRI, and tPA significantly decreased; HDL cholesterol significantly increased after NSPT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). HDL cholesterol, vWf, IL\u20106, and sTNFRII levels remained significantly different from those of the healthy group at 6\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NSPT improved periodontal status; however, systemic biomarkers did not uniformly return to health reference levels, indicating a need for a more comprehensive medical approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70524","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:15:57Z","timestamp":1790741757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Biomarker Changes After Non\u2010Surgical Periodontal Treatment in Young Adults With Stage\n                    <scp>III<\/scp>\n                    \/\n                    <scp>IV<\/scp>\n                    Grade C Periodontitis"],"prefix":"10.1111","author":[{"given":"Dilek","family":"Guvenc","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Cintan","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Soguksu","sequence":"additional","affiliation":[{"name":"Department of Virology and Basic Immunology Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9754-2142","authenticated-orcid":false,"given":"Ulku","family":"Baser","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-5411","authenticated-orcid":false,"given":"Silvi","family":"Domnori","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul University  Istanbul T\u00fcrkiye"},{"name":"Department of Periodontology, Institute of Graduate Studies in Health Sciences Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslan Yasar","family":"Gokbuget","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul University  Istanbul 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