{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:50:07Z","timestamp":1791413407752,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To propose a clinical classification system for oral squamous cell carcinoma (OSCC) based on lesion characteristics, aiming to enhance early recognition and initial clinical diagnostic hypothesis rate in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis of 422\n                      <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\n                      cases was conducted from 2005 to 2023. Lesions were clinically categorized through clinical photographs as either \u201cconventional\u201d (including non\u2010ulcerated plaques; red, white, or mixed and ulcerated infiltrative lesions with raised indurated margins) or \u201catypical\u201d (different from the one described above) based on their presentation. Atypical cases were further subclassified into morphological types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 422 OSCC cases, 316 (74.9%) were classified as conventional and 106 (25.1%) as atypical. Conventional cases were predominantly ulcerative or leukoplakic, while atypical cases exhibited fissure\u2010like and exophytic patterns. Tongue border was most commonly affected in conventional OSCC, while floor of the mouth and buccal mucosa predominated in atypical forms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately one\u2010quarter of OSCC cases present with atypical clinical features. The proposed classification provides a practical tool for clinicians to recognize these variants. However, further prospective validation is warranted to determine whether its application improves clinical recognition and diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70532","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:00:46Z","timestamp":1791266446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Variability in Oral Squamous Cell Carcinoma: A Retrospective Analysis Proposing a Practical Morphological Classification"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-8085","authenticated-orcid":false,"given":"Nathalia Felix","family":"de Mendonca","sequence":"first","affiliation":[{"name":"Stomatology Department A. C. Camargo Cancer Center  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-4343","authenticated-orcid":false,"given":"Paulo Rogerio Ferreti","family":"Bonan","sequence":"additional","affiliation":[{"name":"Dentistry Post Graduation Program Universidade Federal da Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-2802","authenticated-orcid":false,"given":"Herc\u00edlio Martelli","family":"Junior","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Dental School, State University of Montes Claros  Montes Claros Minas Gerais Brazil"},{"name":"Center for Rehabilitation of Craniofacial Anomalies Dental School, University of Jos\u00e9 Rosario Vellano  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-4645","authenticated-orcid":false,"given":"Danyel Elias da Cruz","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Clinical and Preventive Dentistry Universidade Federal de Pernambuco (UFPE)  Recife Pernambuco Brazil"},{"name":"Department of Oral Diagnosis Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-6000","authenticated-orcid":false,"given":"Alessandro","family":"Villa","sequence":"additional","affiliation":[{"name":"Herbert Wertheim Cancer Institute Baptist Health South Florida  Miami Florida USA"},{"name":"Herbert Wertheim College of Medicine Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-156X","authenticated-orcid":false,"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Otorhinolaryngology A.C. Camargo Cancer Center  S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Head and Neck Surgery Universidade de S\u00e3o Paulo Medical School  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-0065","authenticated-orcid":false,"given":"M\u00e1rcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-8878","authenticated-orcid":false,"given":"Fabio Ramoa","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Dentistry, Rio de Janeiro State University  Rio de Janeiro Brazil"},{"name":"Post\u2010Graduation Program in Dentistry Est\u00e1cio de S\u00e1 University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-1536","authenticated-orcid":false,"given":"Fabio Abreu","family":"Alves","sequence":"additional","affiliation":[{"name":"Stomatology Department A. C. Camargo Cancer Center  S\u00e3o Paulo SP Brazil"},{"name":"Herbert Wertheim Cancer Institute Baptist Health South Florida  Miami Florida USA"},{"name":"Stomatology Department, Dentistry School S\u00e3o Paulo University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14971"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.03.009"},{"key":"e_1_2_10_4_1","volume-title":"Cancer of the Mouth","author":"Barbosa J. F.","year":"1968"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-13620-2_5"},{"key":"e_1_2_10_6_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar A. 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