{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:51:07Z","timestamp":1791535867795,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Conventional topical therapies for oral ulcers remain limited due to poor mucosal adhesion and rapid clearance by saliva. To overcome these challenges, we aimed to develop a microneedle patch with \u03b1\u2010boswellic acid for targeted anti\u2010inflammatory treatment of oral ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The microneedle patch was fabricated and evaluated for mechanical strength and drug release profile. Biocompatibility was assessed. In\u00a0vitro anti\u2010inflammatory activity was examined in macrophages. In\u00a0vivo efficacy was tested using a rat oral ulcer model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The \u03b1\u2010boswellic acid\u2010loaded hyaluronic acid methacryloyl microneedle patch displayed adequate mechanical properties and sustained drug release. It exhibited favorable biocompatibility with low cytotoxicity and no apparent adverse effects on fibroblast migration. In\u00a0vitro, the patch significantly inhibited pro\u2010inflammatory cytokine and promoted M2 polarization. The patch accelerated ulcer healing, reducing the unhealed wound area in\u00a0vivo. Enhanced collagen deposition and stimulated neovascularization were observed. Histological results demonstrated organized tissue regeneration, decreased neutrophil infiltration, and shifted macrophage phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The \u03b1\u2010boswellic acid\u2010loaded hyaluronic acid methacryloyl microneedle patch effectively combines the anti\u2010inflammatory activity of \u03b1\u2010boswellic acid with the minimally invasive delivery advantages of the microneedle. This approach addresses key limitations of current topical treatments, demonstrating a promising therapeutic strategy for clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.70540","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:19:56Z","timestamp":1791533996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyaluronic Acid Microneedle With \u03b1\u2010Boswellic Acid Heal Oral Ulcers by Anti\u2010inflammatory Activity"],"prefix":"10.1111","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oral Medicine First Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoqun","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine First Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine First Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4983-4434","authenticated-orcid":false,"given":"Xiaojun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine First Hospital of Shanxi Medical University  Taiyuan Shanxi 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