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Mucosal inflammation is a hallmark response of the host seen in chronic diseases, such as colitis, gingivitis, and periodontitis (and the related disorder peri\u2010implantitis). We have taken advantage of our recently developed rat model of human peri\u2010implantitis that recapitulates osteolysis, the requirement of biofilm formation, and the perpetuation of the <jats:italic>bona fide<\/jats:italic> disease state, to test a new therapeutic modality with two novel components. First we used hyperimmune antiserum directed against the <jats:styled-content style=\"fixed-case\">DNABII<\/jats:styled-content> family of proteins, now known to be a critical component of the extracellular matrix of bacterial biofilms. Second we delivered the antiserum as cargo in biodegradable microspheres to the site of the biofilm infection. We demonstrated that delivery of a single dose of anti\u2010<jats:styled-content style=\"fixed-case\">DNABII<\/jats:styled-content> in poly(lactic\u2010co\u2010glycolic acid) (<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content>) microspheres induced significant resolution of experimental peri\u2010implantitis, including marked reduction of inflammation. These data support the continued development of a <jats:styled-content style=\"fixed-case\">DNABII<\/jats:styled-content> protein\u2010targeted therapeutic for peri\u2010implantitis and other chronic inflammatory pathologies of the oral cavity in animals and humans.<\/jats:p>","DOI":"10.1111\/omi.12155","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T07:12:38Z","timestamp":1456902758000},"page":"74-88","source":"Crossref","is-referenced-by-count":51,"title":["A bacterial\u2010biofilm\u2010induced oral osteolytic infection can be successfully treated by immuno\u2010targeting an extracellular nucleoid\u2010associated protein"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4906-7698","authenticated-orcid":false,"given":"M.O.","family":"Freire","sequence":"first","affiliation":[{"name":"Department of Applied Oral Sciences The Forsyth Institute Cambridge MA USA"},{"name":"Department of Infection and Immunity Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Periodontology Diagnostic Sciences &amp; Dental Hygiene Ostrow School of Dentistry University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Downey","sequence":"additional","affiliation":[{"name":"Division of Periodontology Diagnostic Sciences &amp; Dental Hygiene Ostrow School of Dentistry University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Periodontology Diagnostic Sciences &amp; Dental Hygiene Ostrow School of Dentistry University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.O.","family":"Bakaletz","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.H.","family":"Zadeh","sequence":"additional","affiliation":[{"name":"Division of Periodontology Diagnostic Sciences &amp; Dental Hygiene Ostrow School of Dentistry University of Southern California Los Angeles CA USA"},{"name":"Laboratory for Immunoregulation and Tissue Engineering (LITE) University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.D.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01645.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2010.09.026"},{"key":"e_1_2_8_4_1","first-page":"470","article-title":"An investigation of tissue tolerance to titanium metal implants in dogs","volume":"39","author":"Beder O.E.","year":"1956","journal-title":"Surgery"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300647"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01397.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01847.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00384-09"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24183"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. 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